Table 3.

Common changes in gene expression induced by traumatic injury of hippocampus and spinal cord

Accession No.GeneHPC (trauma)SC (trauma)ClassificationFunction
X54686*Jun B proto-oncogene (Junb)transcription translationtranscriptional activator
L26267*Nuclear factor kappa B p105 subunit (Nfkb1)transcription translationtranscriptional activator
M34253*Interferon regulatory factor 1 (Irf1)transcription translationtranscription factor
M18416*Early growth response 1 (Egr1, Krox24, NGFI-A)transcription translationtranscription factor
X60769*CCAAT/enhancer binding protein (Cebpg)transcription translationsilencer factor
X06769*c-fostranscription translationtranscriptional activator
AF013144*MAP-kinase phosphatase (Cpg21)signal transductionMAP kinase phosphatase
U22414*Small inducible cytokine A3 (Ccl3)inflammationneutrophil recruitment
U45965*Small inducible cytokine B2 (Cxcl2)inflammationneutrophil recruitment
M98820*Interleukin 1 beta (Il1b)inflammationproinflammatory cytokine
L23088*P-selectin (Selp)inflammationrecruitment of inflammatory cells
J02722*Heme oxigenase (Hmox1)metabolismheme catabolism
M15880*Neuropeptide Y (Npy)neuropeptidescontrol of food intake, reduces activity-dependent release of glutamate, nociception
M34384*Nestin (Nes)cytoskeletonstem cell intermediate filament
AF030091*Cyclin ania-6a (Ccnl)cell cyclecell cycle regulator
D00913*Intercellular adhesion molecule 1 (Icam1)membrane proteinsintercellular adhesion molecule
X54656AMPA receptor alpha 3 (Gria3)receptorsAMPA selective glutamate receptor
M36418AMPA receptor alpha 1 (Gria1)receptorsAMPA selective glutamate receptor
M92076*mGluR3 (Grm3)receptorsmetabotropic glutamate receptor
AB003992*SNAP-25Bmembrane proteinsneurosecretion
AB003991*SNAP-25Amembrane proteinsneurosecretion
AF021923*Slc24a2channels and transporterspotassium-dependent sodium/calcium exchanger
M59980K+ voltage gated channel Shal-related family, member 2 (Kcnd2)channels and transportersregulator of excitability
S83194*Calcium/calmodulin-dependent protein kinase kinase 1, alpha (Camkk1)signal transductioncalcium signaling
M16112Calcium/calmodulin-dependent protein kinase II beta subunit (Camk2b)signal transductioncalcium signaling
X17682Microtubule-associated protein 2 (Mtap2)cytoskeletonneuronal microtubule-associated protein
AF022819*Putative potassium channel TWIK (Kcnk1)channels and transportersregulator of excitability
M25638Neurofilament, light polypeptide (Nfl)cytoskeletonneurofilament protein
  • Up arrows indicate significant upregulation compared with control; down arrows indicate significant downregulation compared with control. Transcripts found to be altered after acute ischemia in cerebral cortex (Ref. 26) are indicated by an asterisk. HPC, hippocampus; SC, spinal cord.