Table 1.

Phenotypic values in parental strains and F1 crosses

TraitMalesFemales
A/JC57BL/6JAB6F1B6AF1A/JC57BL/6JAB6F1B6AF1
BW, g23.6 (2.1)22.9 (2.0)28.5 (2.4)24.6 (0.8)17.6 (1.1)18.6 (0.9)21.9 (0. 8)19.9 (1.6)
LVW/BW2.69 (0.33)3.41 (0.31)3.46 (0.16)3.51 (0.22)3.05 (0.12)3.39 (0.16)3.70 (0.20)4.04 (0.30)
RVW/BW0.87 (0.14)0.81 (0.17)0.84 (0.10)0.91 (0.11)0.92 (0.14)0.84 (0.13)0.90 (0.10)1.10 (0.10)
CM area, μm22,825 (87)3,682 (121)3,105 (55)2,737 (122)2,599 (54)2,826 (51)*2,602 (68)2,757 (62)
CM length, μm133.2 (2.0)160.1 (1.6)144.7 (2.1)132.9 (1.8)125.8 (0.9)136.4 (1.2)132.5 (1.1)135.1 (1.8)
CM width, μm21.1 (0.5)22.9 (0.6)21.3 (0.1)20.5 (0.7)20.7 (0.3)20.6 (0.3)19.6 (0.4)20.4 (0.3)
MAP, mmHg105.4 (2.6)115.6 (5.1)*115.8 (7.5)100.0 (5.0)*114.2 (2.9)108.2 (2.8)103.5 (2.0)105.5 (4.7)
DBP, mmHg90.2 (3.3)101.7 (7.7)106.7 (7.3)89.5 (3.4)*98.8 (4.4)90.7 (2.8)87.3 (2.1)87.8 (5.9)
SBP, mmHg118.4 (2.0)128.6 (2.9)*124.8 (8.6)110.9 (5.5)128.0 (3.4)123.7 (3.5)117.8 (1.9)121.6 (3.0)
PP, mmHg27.7 (0.9)26.8 (4.8)17.8 (1.2)21.1 (5.5)27.2 (8.0)33.0 (2.9)30.5 (2.0)33.7 (4.7)
HR, beats/min580 (43)586 (43)536 (9)537 (15)671 (31)606 (29)577 (21)584 (48)
  • Results are means (SD). BW, body weight; LVW, left ventricular weight; RVW, right ventricular weight; CM, cardiomyocyte; MAP, mean arterial pressure; DBP, diastolic blood pressure; SBP, systolic blood pressure; PP, pulse pressure; HR, heart rate. For all traits, differences are between parental strains or between reciprocal F1 crosses in each sex.

  • * P < 0.05;

  • P < 0.01;

  • P < 0.001.