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Contents: Volume 38, Release 1; June 2009
[Index by Author]
[Editorial Board]
[Cover Caption]
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= article is free immediately upon publication
(all articles are free one year after publication)
Cover: Vascular endothelial growth factor VEGF (blue) and its soluble receptor sVEGFR1 (orange) are key molecules that regulate angiogenesis, the growth of new capillaries from pre-existent microvasculature. In our computational model of the systems biology of VEGF, a system of 61 ordinary differential equations describes the interactions between VEGF, sVEGFR1, and other VEGF receptors (VEGFR1, VEGFR2, neuropilin-1, matrix proteoglycans), as well as intercompartmental transport processes (vascular permeability, lymphatic drainage, plasma clearance). A selection of these molecular interactions and transport processes is illustrated in the middle row. Solutions to the mathematical equations allow the prediction of in vivo systemic distributions of VEGF-among body compartments (e.g., interstitial fluid in muscle tissue vs. plasma) and among its various molecular binding partners (e.g., free vs. sVEGFR1-bound vs. bound to endothelial cell surface receptors)-under varying conditions of protein expression rates (e.g., endogenous production rates of sVEGFR1 in the x- and y-axes of the 3-dimensional plots) and transport rates (e.g., +Ctrl vs. E1 vs. E2 vs. E3 in the 3-dimensional plots). For details, see Wu FT, Stefanini MO, Mac Gabhann F, Kontos CD, Annex BH, Popel AS. A computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport. Physiol Genomics 38: 29–41, 2009 (first published April 7, 2009; doi:10.1152/physiolgenomics.00031.2009).
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