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Contents: Volume 40, Release 3; February 2010
[Index by Author]
[Editorial Board]
[Cover Caption]
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= article is free immediately upon publication
(all articles are free one year after publication)
Cover: A Caenorhabditis elegans muscle cell stained for myosin-rich thick filaments (green) and actin-rich thin filaments (red). Krajacic et al. demonstrate that C. elegans fer-1, which encodes the founding member of the Dysferlin family and was previously thought to be expressed only in C. elegans sperm, is also expressed in worm muscle cells. The authors further demonstrate that fer-1 mutations, like human Dysferlin mutations, also give rise to large-scale transcriptional alterations in muscle expressed genes. Since mutations in the human Dysferlin gene cause an incurable form of limb girdle muscular dystrophy, these studies suggest that the C. elegans system may provide a powerful genetic platform to dissect the muscle-specific functions of this poorly understood protein. For details see Krajacic P, Hermanowski J, Lozynska O, Khurana TS, and Lamitina T. C. elegans dysferlin homolog fer-1 is expressed in muscle, and fer-1 mutations initiate altered
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