Physiol. Genomics -- Table of Contents (December 2008, 36 [1])

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Call For Papers: Translational Physiology:

Ru Yang, Jawaria Amir, Haibo Liu, and Brahim Chaqour: Mechanical strain activates a program of genes functionally involved in paracrine signaling of angiogenesis
Physiol. Genomics 36: 1-14, 2008. First published October 14, 2008; doi:10.1152/physiolgenomics.90291.2008 [Abstract] [Full Text] [PDF]

Research Articles:

Pascal J. H. Smeets, Heleen M. de Vogel-van den Bosch, Peter H. M. Willemsen, Alphons P. Stassen, Torik Ayoubi, Ger J. van der Vusse, and Marc van Bilsen: Transcriptomic analysis of PPAR ${alpha}$ -dependent alterations during cardiac hypertrophy
Physiol. Genomics 36: 15-23, 2008. First published September 23, 2008; doi:10.1152/physiolgenomics.90296.2008 [Abstract] [Full Text] [PDF] [Supplemental Figures and Tables]

Wei Wu, Nilesh B. Dave, Guoying Yu, Patrick J. Strollo, Elizabeta Kovkarova-Naumovski, Stefan W. Ryter, Stephen R. Reeves, Ehab Dayyat, Yang Wang, Augustine M. K. Choi, David Gozal, and Naftali Kaminski: Network analysis of temporal effects of intermittent and sustained hypoxia on rat lungs
Physiol. Genomics 36: 24-34, 2008. First published September 30, 2008; doi:10.1152/physiolgenomics.00258.2007 [Abstract] [Full Text] [PDF] [Supplemental Figures and Tables]

A. J. Kriegel and A. S. Greene: Substitution of Brown Norway chromosome 16 preserves cardiac function with aging in a salt-sensitive Dahl consomic rat
Physiol. Genomics 36: 35-42, 2008. First published October 21, 2008; doi:10.1152/physiolgenomics.00054.2008 [Abstract] [Full Text] [PDF]

Yumi Imai, Hiral R. Patel, Nicolai M. Doliba, Franz M. Matschinsky, John W. Tobias, and Rexford S. Ahima: Analysis of gene expression in pancreatic islets from diet-induced obese mice
Physiol. Genomics 36: 43-51, 2008. First published October 14, 2008; doi:10.1152/physiolgenomics.00050.2008 [Abstract] [Full Text] [PDF] [Supplemental Tables]

Yong Liu, Ravinder J. Singh, Kristie Usa, Brian C. Netzel, and Mingyu Liang: Renal medullary 11β-hydroxysteroid dehydrogenase type 1 in Dahl salt-sensitive hypertension
Physiol. Genomics 36: 52-58, 2008. First published September 30, 2008; doi:10.1152/physiolgenomics.90283.2008 [Abstract] [Full Text] [PDF] [Supplemental Material]

Cover Caption:

Cover

Cover: shown is a female goldfish (Carassius auratus) in front of a carp/goldfish cDNA microarray developed in the AURATUS Goldfish Genomics project (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GPL3735). This platform was used to analyze the hypothalamic transcriptome in female goldfish injected with the antidepressant fluoxetine. Traces of this pharmaceutical have recently been detected in the aquatic environment. The study revealed effects on the reproductive axis in goldfish, in particular disruption of circulating estrogen. Analysis of the hypothalamic transcriptome identified the reproductive neuropeptide isotocin as being downregulated in the hypothalamus. Additional studies revealed that isotocin stimulates circulating estradiol, providing a potential mechanism for the observed decrease in estradiol. For details see Mennigen JA, Martyniuk CJ, Crump K, Xiong H, Zhao E, Popesku J, Anisman H, Cossins AR, Xia X, Trudeau VL. Effects of fluoxetine on the reproductive axis of female goldfish (Carassius auratus). Physiol Genomics 35: 273-282, 2008 (first published September 2, 2008) doi:10.1152/physiolgenomics.90263.2008.