Physiol. Genomics -- Table of Contents (September 2008, 35 [1])

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Perspective:

Willem J. de Lange, Carmen M. Halabi, Andreas M. Beyer, and Curt D. Sigmund: Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles
Physiol. Genomics 35: 1-4, 2008. First published July 8, 2008; doi:10.1152/physiolgenomics.90284.2008 [Abstract] [Full Text] [PDF]

Call For Papers: Comparative Genomics:

Stian Ellefsen, Guro K. Sandvik, Helene K. Larsen, Kåre-Olav Stensløkken, Dag Are S. Hov, Tom A. Kristensen, and Göran E. Nilsson: Expression of genes involved in excitatory neurotransmission in anoxic crucian carp (Carassius carassius) brain
Physiol. Genomics 35: 5-17, 2008. First published July 1, 2008; doi:10.1152/physiolgenomics.90221.2008 [Abstract] [Full Text] [PDF]

Helen Evans, Tony De Tomaso, Mike Quail, Jane Rogers, Andrew Y. Gracey, Andrew R. Cossins, and Michael Berenbrink: Ancient and modern duplication events and the evolution of stearoyl-CoA desaturases in teleost fishes
Physiol. Genomics 35: 18-29, 2008. First published July 1, 2008; doi:10.1152/physiolgenomics.90266.2008 [Abstract] [Full Text] [PDF] [Supplemental Table]

Angela Schulz, Jonna Hänsch, Kristina Kuhn, Maria Schlesener, Peter Kossmehl, Jens R. Nyengaard, Norbert Wendt, Matthias Huber, and Reinhold Kreutz: Nephron deficit is not required for progressive proteinuria development in the Munich Wistar Frömter rat
Physiol. Genomics 35: 30-35, 2008. First published July 22, 2008; doi:10.1152/physiolgenomics.90270.2008 [Abstract] [Full Text] [PDF]

Gunther De Mars, An Windelinckx, Wim Huygens, Maarten W. Peeters, Gaston P. Beunen, Jeroen Aerssens, Robert Vlietinck, and Martine A. I. Thomis: Genome-wide linkage scan for contraction velocity characteristics of knee musculature in the Leuven Genes for Muscular Strength Study
Physiol. Genomics 35: 36-44, 2008. First published August 5, 2008; doi:10.1152/physiolgenomics.90252.2008 [Abstract] [Full Text] [PDF]

Research Articles:

Carley R. Benton, Yuko Yoshida, James Lally, Xiao-Xia Han, Hideo Hatta, and Arend Bonen: PGC-1 ${alpha}$ increases skeletal muscle lactate uptake by increasing the expression of MCT1 but not MCT2 or MCT4
Physiol. Genomics 35: 45-54, 2008. First published June 3, 2008; doi:10.1152/physiolgenomics.90217.2008 [Abstract] [Full Text] [PDF]

Nicki Tiffin, Ikechi Okpechi, Carolina Perez-Iratxeta, Miguel A. Andrade-Navarro, and Rajkumar Ramesar: Prioritization of candidate disease genes for metabolic syndrome by computational analysis of its defining phenotypes
Physiol. Genomics 35: 55-64, 2008. First published July 8, 2008; doi:10.1152/physiolgenomics.90247.2008 [Abstract] [Full Text] [PDF] [Supplemental Tables]

Natsuko Hada, Misato Kobayashi, Masato Fujiyoshi, Akira Ishikawa, Masako Kuga, Masahiko Nishimura, Shizufumi Ebihara, Tamio Ohno, and Fumihiko Horio: Quantitative trait loci for impaired glucose tolerance in nondiabetic SM/J and A/J mice
Physiol. Genomics 35: 65-74, 2008. First published July 15, 2008; doi:10.1152/physiolgenomics.00027.2008 [Abstract] [Full Text] [PDF] [Supplemental Table]

Santanu Chakraborty, Jonathan Cheek, Bhuvaneswari Sakthivel, Bruce J. Aronow, and Katherine E. Yutzey: Shared gene expression profiles in developing heart valves and osteoblast progenitor cells
Physiol. Genomics 35: 75-85, 2008. First published July 8, 2008; doi:10.1152/physiolgenomics.90212.2008 [Abstract] [Full Text] [PDF] [Supplemental Figures and Tables]

Marianna Evans, Kevin Morine, Cyelee Kulkarni, and Elisabeth R. Barton: Expression profiling reveals heightened apoptosis and supports fiber size economy in the murine muscles of mastication
Physiol. Genomics 35: 86-95, 2008. First published July 1, 2008; doi:10.1152/physiolgenomics.00232.2007 [Abstract] [Full Text] [PDF]

Masanori Fuse, Norihide Yokoi, Masami Shinohara, Taku Masuyama, Riko Kitazawa, Sohei Kitazawa, and Susumu Seino: Identification of a major locus for islet inflammation and fibrosis in the spontaneously diabetic Torii rat
Physiol. Genomics 35: 96-105, 2008. First published July 8, 2008; doi:10.1152/physiolgenomics.90214.2008 [Abstract] [Full Text] [PDF] [Supplemental Figures and Tables]

May Christine V. Malicdan, Satoru Noguchi, Yukiko K. Hayashi, and Ichizo Nishino: Muscle weakness correlates with muscle atrophy and precedes the development of inclusion body or rimmed vacuoles in the mouse model of DMRV/hIBM
Physiol. Genomics 35: 106-115, 2008. First published July 15, 2008; doi:10.1152/physiolgenomics.90219.2008 [Abstract] [Full Text] [PDF] [Supplemental Figures]

David A. Buchner, Lindsay C. Burrage, Annie E. Hill, Soha N. Yazbek, William E. O'Brien, Colleen M. Croniger, and Joseph H. Nadeau: Resistance to diet-induced obesity in mice with a single substituted chromosome
Physiol. Genomics 35: 116-122, 2008. First published July 15, 2008; doi:10.1152/physiolgenomics.00033.2008 [Abstract] [Full Text] [PDF] [Supplemental Figures and Tables]

Steven M. Swift, Brigitte R. Gaume, Kersten M. Small, Bruce J. Aronow, and Stephen B. Liggett: Differential coupling of Arg- and Gly389 polymorphic forms of the β₁-adrenergic receptor leads to pathogenic cardiac gene regulatory programs
Physiol. Genomics 35: 123-131, 2008. First published July 29, 2008; doi:10.1152/physiolgenomics.90225.2008 [Abstract] [Full Text] [PDF] [Supplemental Figures and Tables]

Cover Caption:

Cover

Cover: Shown is the tentative tertiary structure of the extracellular glycine-binding S1S2 segment of crucian carp NR1 subunit, which is a part of the NMDA glutamatergic neurotransmitter receptor. The NMDA receptor promotes anoxic brain damage, and since the crucian carp is one of the most anoxia-tolerant vertebrates there is, it is possible that NMDA receptor function is modified in the animal. Crystal structure for rat NR1 S1S2 was used as template. Red side-chains/letters indicate differences in amino acid composition between crucian carp and rat. The orange regions indicate the parts of S1S2 that leaves/enters the cell membrane. The green region indicates loop 1 of the S1S2 fragment, where a novel splice cassette (including an N-glycosylation site that is highlighted by the red box) was found in some crucian carp NR1. For details, see Ellefsen S, Sandvik GK, Larsen HK, Stensl�kken K-O, Hov DA, Kristensen TA, and Nilsson GE. Expression of genes involved in excitatory neurotransmission in anoxic crucian carp (Carassius carassius) brain. Physiol Genomics 35: 5�17, 2008 (first published July 1, 2008; doi:10.1152/physiolgenomics.90221.2008).