Physiol. Genomics -- Table of Contents (April 22 2008, 33 [2])

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Reviews:

Chunxiang Zhang: MicroRNomics: a newly emerging approach for disease biology
Physiol. Genomics 33: 139-147, 2008. First published February 26, 2008; doi:10.1152/physiolgenomics.00034.2008 [Abstract] [Full Text] [PDF]

Research Articles:

Jing Chen, Sara A. Carney, Richard E. Peterson, and Warren Heideman: Comparative genomics identifies genes mediating cardiotoxicity in the embryonic zebrafish heart
Physiol. Genomics 33: 148-158, 2008. First published January 29, 2008; doi:10.1152/physiolgenomics.00214.2007 [Abstract] [Full Text] [PDF] [Supplemental Tables]

Peter G. Fuhrken, Chi Chen, Pani A. Apostolidis, Min Wang, William M. Miller, and Eleftherios T. Papoutsakis: Gene Ontology-driven transcriptional analysis of CD34⁺ cell-initiated megakaryocytic cultures identifies new transcriptional regulators of megakaryopoiesis
Physiol. Genomics 33: 159-169, 2008. First published February 5, 2008; doi:10.1152/physiolgenomics.00127.2007 [Abstract] [Full Text] [PDF] [Supplemental Figures]

Camille Brochier, Marie-Claude Gaillard, Elsa Diguet, Nicolas Caudy, Carole Dossat, Béatrice Ségurens, Patrick Wincker, Emmanuel Roze, Jocelyne Caboche, Philippe Hantraye, Emmanuel Brouillet, Jean-Marc Elalouf, and Michel de Chaldée: Quantitative gene expression profiling of mouse brain regions reveals differential transcripts conserved in human and affected in disease models
Physiol. Genomics 33: 170-179, 2008. First published February 5, 2008; doi:10.1152/physiolgenomics.00125.2007 [Abstract] [Full Text] [PDF] [Supplemental Table and Figures]

Satish A. Eraly, Volker Vallon, Timo Rieg, Jon A. Gangoiti, William R. Wikoff, Gary Siuzdak, Bruce A. Barshop, and Sanjay K. Nigam: Multiple organic anion transporters contribute to net renal excretion of uric acid
Physiol. Genomics 33: 180-192, 2008. First published February 12, 2008; doi:10.1152/physiolgenomics.00207.2007 [Abstract] [Full Text] [PDF]

N. Forde, M. Mihm, M. J. Canty, A. E. Zielak, P. J. Baker, S. Park, P. Lonergan, G. W. Smith, P. M. Coussens, J. J. Ireland, and A. C. O. Evans: Differential expression of signal transduction factors in ovarian follicle development: a functional role for betaglycan and FIBP in granulosa cells in cattle
Physiol. Genomics 33: 193-204, 2008. First published February 19, 2008; doi:10.1152/physiolgenomics.00274.2007 [Abstract] [Full Text] [PDF]

Takashi Kuramoto, Satoshi Nakanishi, and Tadao Serikawa: Functional polymorphisms in inbred rat strains and their allele frequencies in commercially available outbred stocks
Physiol. Genomics 33: 205-211, 2008. First published January 22, 2008; doi:10.1152/physiolgenomics.00222.2007 [Abstract] [Full Text] [PDF] [Supplemental Figure]

S. Gilibert, A. E. Kwitek, N. Hubner, M. Tschannen, H. J. Jacob, J. Sassard, and A. Bataillard: Effects of chromosome 17 on features of the metabolic syndrome in the Lyon hypertensive rat
Physiol. Genomics 33: 212-217, 2008. First published February 19, 2008; doi:10.1152/physiolgenomics.00262.2007 [Abstract] [Full Text] [PDF] [Supplemental Table]

Jeong-In Lee, John E. Dominy, Jr., Angelos K. Sikalidis, Lawrence L. Hirschberger, Wei Wang, and Martha H. Stipanuk: HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway
Physiol. Genomics 33: 218-229, 2008. First published February 19, 2008; doi:10.1152/physiolgenomics.00263.2007 [Abstract] [Full Text] [PDF] [Supplemental Figure and Table]

Jacques M. Lignon, Zoë Bichler, Bruno Hivert, François E. Gannier, Pierre Cosnay, José A. del Rio, Danièle Migliore-Samour, and Claire O. Malécot: Altered heart rate control in transgenic mice carrying the KCNJ6 gene of the human chromosome 21
Physiol. Genomics 33: 230-239, 2008. First published February 26, 2008; doi:10.1152/physiolgenomics.00143.2007 [Abstract] [Full Text] [PDF]

Winnie S. Liang, Travis Dunckley, Thomas G. Beach, Andrew Grover, Diego Mastroeni, Keri Ramsey, Richard J. Caselli, Walter A. Kukull, Daniel McKeel, John C. Morris, Christine M. Hulette, Donald Schmechel, Eric M. Reiman, Joseph Rogers, and Dietrich A. Stephan: Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set
Physiol. Genomics 33: 240-256, 2008. First published February 12, 2008; doi:10.1152/physiolgenomics.00242.2007 [Abstract] [Full Text] [PDF]

Bo Liang, Franca Chung, Yang Qu, Dmitri Pavlov, Todd E. Gillis, Svetlana B. Tikunova, Jonathan P. Davis, and Glen F. Tibbits: Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca²⁺ binding and myofilament contractility
Physiol. Genomics 33: 257-266, 2008. First published February 19, 2008; doi:10.1152/physiolgenomics.00154.2007 [Abstract] [Full Text] [PDF] [Supplemental Figure]

Georges E. Haddad, Lori J. Saunders, Seth D. Crosby, Maria Carles, Federica del Monte, Kindra King, Michael R. Bristow, Francis G. Spinale, Thomas E. Macgillivray, Marc J. Semigran, G. William Dec, Steven A. Williams, Roger J. Hajjar, and Judith K. Gwathmey: Human cardiac-specific cDNA array for idiopathic dilated cardiomyopathy: sex-related differences
Physiol. Genomics 33: 267-277, 2008. First published February 26, 2008; doi:10.1152/physiolgenomics.00265.2007 [Abstract] [Full Text] [PDF] [Supplemental Table]

Liliana Moreno-Vinasco, Mardi Gomberg-Maitland, Michael L. Maitland, Ankit A. Desai, Patrick A. Singleton, Saad Sammani, Lee Sam, Yang Liu, Aliya N. Husain, Roberto M. Lang, Mark J. Ratain, Yves A. Lussier, and Joe G. N. Garcia: Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertension
Physiol. Genomics 33: 278-291, 2008. First published February 26, 2008; doi:10.1152/physiolgenomics.00169.2007 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figures]

Toolbox:

Jeffrey R. Peterson, David W. Infanger, Valdir A. Braga, Yulong Zhang, Ram V. Sharma, John F. Engelhardt, and Robin L. Davisson: Longitudinal noninvasive monitoring of transcription factor activation in cardiovascular regulatory nuclei using bioluminescence imaging
Physiol. Genomics 33: 292-299, 2008. First published January 29, 2008; doi:10.1152/physiolgenomics.00296.2007 [Abstract] [Full Text] [PDF]

Cover Caption:

Cover

Cover: In vivo bioluminescence imaging in combination with virally mediated delivery of luciferase reporters enables longitudinal mapping of transcription factor activity in discrete brain nuclei. After viral targeting of luciferase reporters of transcription factor activation to central cardiovascular regulatory nuclei (top, mouse brain section image courtesy of The Mouse Brain Library), bioluminescence measurements may be taken concurrently with physiological assessments, such as arterial pressure (bottom), in the same animal over time. This approach has the potential to reveal novel links between changes in transcription factor activation patterns in the central nervous system and functional physiologic outcomes. For details, see Peterson JR, Infanger DW, Braga VA, Zhang Y, Sharma RV, Engelhardt JF, and Davisson RL. Longitudinal noninvasive monitoring of transcription factor activation in cardiovascular regulatory nuclei using bioluminescence imaging. Physiol Genomics first published January 29, 2008; doi:10.1152/physiolgenomics.00296.2007.