Physiol. Genomics -- Table of Contents (October 11 2006, 27 [2])

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Research Articles:

Timo A. Lakka, Tuomo Rankinen, Treva Rice, Arthur S. Leon, D. C. Rao, James S. Skinner, and Claude Bouchard: Quantitative trait locus on chromosome 20q13 for plasma levels of C-reactive protein in healthy whites: the HERITAGE Family Study
Physiol. Genomics 27: 103-107, 2006. First published July 5, 2006; doi:10.1152/physiolgenomics.00054.2005 [Abstract] [Full Text] [PDF]

Speranza Rubattu, Norbert Hubner, Ursula Ganten, Anna Evangelista, Rosita Stanzione, Emanuele Di Angelantonio, Ralph Plehm, Reika Langanki, Elisabetta Gianazza, Luigi Sironi, Giulia D’Amati, and Massimo Volpe: Reciprocal congenic lines for a major stroke QTL on rat chromosome 1
Physiol. Genomics 27: 108-113, 2006. First published July 11, 2006; doi:10.1152/physiolgenomics.00086.2006 [Abstract] [Full Text] [PDF]

Jung-Jun Park, Jason R. Berggren, Matthew W. Hulver, Joseph A Houmard, and Eric P. Hoffman: GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle
Physiol. Genomics 27: 114-121, 2006. First published July 18, 2006; doi:10.1152/physiolgenomics.00045.2006 [Abstract] [Full Text] [PDF] [Supplement Tables]

Brad A. Rikke, Matthew E. Battaglia, David B. Allison, and Thomas E. Johnson: Murine weight loss exhibits significant genetic variation during dietary restriction
Physiol. Genomics 27: 122-130, 2006. First published July 18, 2006; doi:10.1152/physiolgenomics.00068.2006 [Abstract] [Full Text] [PDF] [Supplement Materials]

Yun Wang, Kevin Seburn, Lawrence Bechtel, Bruce Y. Lee, Jin P. Szatkiewicz, Patsy M. Nishina, and Jürgen K. Naggert: Defective carbohydrate metabolism in mice homozygous for the tubby mutation
Physiol. Genomics 27: 131-140, 2006. First published July 18, 2006; doi:10.1152/physiolgenomics.00239.2005 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figures]

Anders Stegmann, Morten Hansen, Yulan Wang, Janus B. Larsen, Leif R. Lund, Léa Ritié, Jeremy K. Nicholson, Bjørn Quistorff, Patricia Simon-Assmann, Jesper T. Troelsen, and Jørgen Olsen: Metabolome, transcriptome, and bioinformatic cis-element analyses point to HNF-4 as a central regulator of gene expression during enterocyte differentiation
Physiol. Genomics 27: 141-155, 2006. First published July 25, 2006; doi:10.1152/physiolgenomics.00314.2005 [Abstract] [Full Text] [PDF] [Supplementary Tables]

Stephan Schiekofer, Ichiro Shiojima, Kaori Sato, Gennaro Galasso, Yuichi Oshima, and Kenneth Walsh: Microarray analysis of Akt1 activation in transgenic mouse hearts reveals transcript expression profiles associated with compensatory hypertrophy and failure
Physiol. Genomics 27: 156-170, 2006. First published August 1, 2006; doi:10.1152/physiolgenomics.00234.2005 [Abstract] [Full Text] [PDF]

Dennis W. McGraw, Kevin M. Fogel, Sue Kong, Augusto A. Litonjua, Evangelia G. Kranias, Bruce J. Aronow, and Stephen B. Liggett: Transcriptional response to persistent ß₂-adrenergic receptor signaling reveals regulation of phospholamban, which alters airway contractility
Physiol. Genomics 27: 171-177, 2006. First published July 18, 2006; doi:10.1152/physiolgenomics.00044.2006 [Abstract] [Full Text] [PDF] [Supplement Table]

Helen J. Atherton, Nigel J. Bailey, Wen Zhang, John Taylor, Hilary Major, John Shockcor, Kieran Clarke, and Julian L. Griffin: A combined ¹H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR- ${alpha}$ null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome
Physiol. Genomics 27: 178-186, 2006. First published July 25, 2006; doi:10.1152/physiolgenomics.00060.2006 [Abstract] [Full Text] [PDF] [Supplementary Data]

Cover Caption:

Cover

Cover: Overview of interactions among gene expression profiles in liver and physiological events in visceral adipose, skeletal muscle, and liver tissue during the periparturient period in dairy cows fed ad libitum or provided restricted feeding of moderate-energy diets. Overfeeding of energy prepartum induces chronic hyperinsulinemia, which plays a central role in physiological and molecular adaptations occurring in visceral adipose and liver. These cows have lower capacity to completely oxidize nonesterified fatty acids (NEFA) in liver (↓ ADIPOR2,↓ ACADVL, ↓ ACAA1, ↓ CPT1A mRNA) but have higher capacity to store triacylglycerol postpartum (↑ AGPAT1, ↑ DGAT1, ↑ MTP mRNA). Restricted energy intake prepartum allows for upregulation of fatty acid oxidation, gluconeogenesis, and cholesterogenesis and prevents excessive oxidative stress and DNA damage. Therefore, controlled energy intake prepartum would be advantageous to the cow as the liver “adjusts” its metabolic activity to the onset of parturition. Uncontrolled triacylglycerol accumulation in liver and oxidative stress increases the risk of periparturient health disorders by predisposing the cow to fatty liver and ketosis, which could increase steatotic hepatocyte through upregulation of TP53 mRNA. For details, see Loor JJ, Dann HM, Janovick Guretzky NA, Everts RE, Oliveira R, Green CA, Litherland NB, Rodriguez-Zas SL, Lewin HA, Drackley JK. Plane of nutrition prepartum alters hepatic gene expression and function in dairy cows as assessed by longitudinal transcript and metabolic profiling. Physiol Genomics 27: 29-41, 2006; doi:10.1152/physiolgenomics.00036.2006.