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Contents: Volume 17, Release 2; 13 April 2004
[Index by Author]
[Cover Caption]
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= article is free immediately upon publication
(all articles are free one year after publication)
Cover: Phylogenetic tree and structures of the main retinoblastoma-related (RBR) subfamilies. Mutations in the parkin gene cause autosomal-recessive juvenile parkinsonism. Parkin encodes a ubiquitin-protein ligase characterized by having the RBR domain, composed of two RING fingers plus an IBR/DRIL domain. The tree was generated using the "neighbor-joining" and "maximum parsimony" methods implemented in MEGA 2.1. For additional details, see Marín I, Lucas JI, Gradilla AC, and Ferrús A. Parkin and relatives: the RBR family of ubiquitin ligases. Physiol. Genomics 17: 253-263, 2004; 10.1152/physiolgenomics.00226.2003.
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