Genomic and "Polyomic" Studies of Cardiovascular and Inflammatory Diseases
Associate Editor: Dr. Martin McBride, University of Glasgow (e-mail: [email protected])
This section is focused on studies of 'form' (DNA) contributing to "function" (physiology and pathophysiology) of cardiovascular and immune systems. Original articles, reviews and rapid reports of manuscripts that focus on both (a) single gene/genetic variants and (b) large scale "omic" (genomic, transcriptomic, proteomic and metabolomic) data are solicited. Investigations on topics including, but not limited to, hypertension, the renin-angiotensin system, stroke, heart and vascular phenotypes, immune dysfunction and autoinflammatory disorders such as arthritis, Systemic lupus erythematosus, multiple sclerosis, etc. will be considered. To be in step with contemporary physiological genomic studies, large-scale cell-based or whole organism based studies are encouraged to encompass biological interpretation and, where appropriate, data integration strategies. This may be data generated during development of any organism or investigations into disease pathophysiology. This section is particularly interested in reporting of novel strategies to establish cause-and-effect network relationships, to uncover latent structure within biological data and interpretation in the context of disease pathways that serve as a platform for translational studies in humans. Research can be submitted either as full-length research papers, reviews or rapid reports.
Systems Biology of Exercise
Associate Editor: Dr. Lauren Gerard Koch, University of Michigan (e-mail: [email protected])
Systems Biology of Exercise is a subdiscipline of exercise physiology and systems biology that studies the adaptation to physical exercise and activity at all levels of biological organization, including DNA, RNA, small molecules, genes, proteins, metabolites, cells, tissues, organs, systems, or populations. The focus of this section is on integrating molecular and cellular approaches to understanding physiological changes in function and process in response to exercise, with an emphasis on discovering new pathways, molecular signatures and gene targets. Other topics of interest include the effects of exercise on growth, development, learning, memory, sleep, microbiomes, behavior, aging, and longevity as well as exercise-related adaptations such as thermoregulation, hypoxia, energy substrate/utilization, and nutrition. We are particularly interested in investigations uncovering mechanistic connections between exercise and health and advancing the knowledge base that extends exercise into precision medicine. Special attention will be given to translational studies addressing the effects of exercise on complex disease phenotypes including cardiovascular, metabolic, muscle, skeletal, respiratory, neurodegenerative, mitochondrial, endocrine, immune, reproductive, and cancer. Research can be submitted as full-length research papers, reviews or rapid reports.
Genomics of Metabolic and Tumor/Cancer Traits
Associate Editor: Dr. Leah Solberg Woods, Wake Forest Health (e-mail: [email protected])
The scientific theme of this section encompasses aspects related to the genomics of traits associated with metabolic syndrome including, but not limited to obesity, diabetes, insulin resistance, dyslipidemia. This section also accepts manuscripts on all aspects of tumor/cancer biology. We are interested in articles reporting research conducted in humans, rats, mice and other animal models, as well as in in vitro systems. Research describing genetic mapping, expression analysis, microRNAs and other noncoding RNA and systems biology are welcome. Computational modeling to define pathways leading to metabolic diseases and cancer will be considered in this section. We also solicit manuscripts utilizing many different “omic” approaches including genomic, epigenomic, transcriptomic, metabolomic and proteomic analyses to explore mechanisms of disease. Research can be submitted either as full-length research papers, reviews or rapid reports.
Genetic and Genomics Investigation of Structure and Function of the Kidney
Associate Editor: Dr. Michael Garrett, University of Mississippi Medical Center (e-mail: [email protected])
This section will focus on the investigation of the role of normal and/or pathological conditions of the kidney in model organisms or in humans. Original research for submission can span investigation of genetic and physiological mechanisms of kidney development through pathological changes in the kidney that result from age, acute injury (e.g., ischemia reperfusion injury), or chronic disease conditions, such as obesity, diabetes, and hypertension. All work broadly related to “genetics,” including traditional linkage analysis and GWAS studies, gene expression (e.g., RNA sequencing), gene regulation and epigenetics (e.g., methylation and noncoding/miRNA), and environmental X gene interactions, etc. are welcomed for submission and review by this section. The application of new or cutting-edge genomic technologies to the study of kidney development or disease conditions are also encouraged. Research can be submitted as full-length research papers, reviews or rapid reports.
Physiological and Genetic control of Neural Function
Dr. Justin Grobe, University of Iowa Carver College of Medicine (e-mail: [email protected])
Dr. Colin Young, George Washington University (e-mail: [email protected])
This section is focused on the interaction of physiological and genetic mechanisms in integrated neural function, with a major focus upon the control of cardiovascular and metabolic endpoints by the brain. Areas covered include developmental neuroscience, imaging, behavior, novel targeting methods, autonomic control, and integrative physiology. Research can be submitted either as full-length research papers, reviews or rapid reports.
Physiological Genomics of Cell States and Their Regulation and Single Cell Genomics
Associate Editor: Dr. Hilary Coller, University of California - Los Angeles (e-mail: [email protected])
The theme of this section is Cellular Genomics. Original articles, reviews and rapid reports on different cellular states and their regulation are welcome. Manuscripts will include investigations using systems biology-based approaches such as transcriptomics, proteomics or metabolomics to consider the similarities and differences among cellular states, as well as hypothesis-driven functional studies of cellular states and transitions between them. Examples of topics that would be appropriate for this section include the role of specific signaling pathways in establishing and maintaining cellular states, the role of the extracellular environment in determining cell state, epithelial-to-mesenchymal transition and other examples of cell plasticity, stem-to-progenitor fate differentiation, senescence, proliferation versus quiescence, cancer stem cells, viral infection, and the effects of environmental exposures on cell state. State-of-the-art methods to study the genomics of single cells or engineer induced pluripotent stem cells or other cell types are also topics relevant to this section. Research can be submitted either as full-length research papers, reviews or rapid reports.
Translational and Precision Medicine
Associate Editor: Dr. Sandosh Padmanabhan, University of Glasgow (e-mail: [email protected])
Clinical studies that advance our understanding of underlying perturbed mechanisms of disease or treatment response.
- Genotype directed clinical trials - well powered pilot studies that will direct future larger studies
- Stratified clinical studies using biomarkers derived from genomic, proteomic or metabolomic studies that provide high-quality data on novel pathways
- Studies of drug treatment response in conjunction with genomic or other omic data
- Studies of mechanisms arising from engineered human cells/tissue
Research can be submitted either as full-length research papers, reviews or rapid reports.
Genome-wide Association Studies and Function
Associate Editor: Dr. Patricia Munroe, The London Queen Mary's School of Medicine and Dentistry (e-mail: [email protected])
This section is focused on research that contributes to the discovery and interpretation of genetic variants from genome-wide association studies (GWAS) for understanding physiology and pathophysiology. Reports on all variants are welcome, but this section is especially interested in noncoding genetic variants and mechanistic studies that utilize transcriptomics, chromatin capture methods, methylation, and gene editing using "in vitro" and "in vivo" experiments. This section also invites reports describing new bioinformatics methods and their applications. Research can be submitted either as full-length research papers, reviews or rapid reports.
Associate Editor: Dr. Tim Wiltshire, University of North Carolina Eshelman Schoool of Pharmacy (e-mail: [email protected])
The Pharmacogenomics section covers all aspects of genetic variation and epigenetic variation that impact the way that drugs and xenobiotics are processed and distributed. Articles submitted may include basic research, clinical translation, and applications in drug development. Also solicited are manuscripts on drug response that may include findings in human, animal models and/or cellular studies. Topics of particular interest are:
- Effects of genetic variability on drug toxicity and efficacy
- Pharmacodynamic and pharmacokinetic variations that effect drug efficacy
- Variants in metabolizing enzymes and drug transporters
- Characterization of polymorphisms relevant in drug response
- The metabolism and disposition of biologics as drugs.
Research can be submitted either as full-length research papers, reviews or rapid reports.
Comparative, Statistical and Computational Genomics and Model Organism Databases
Editor: Dr. Bina Joe, University of Toledo College of Medicine (e-mail: [email protected])
This section is dedicated to themes in physiological genomics that are not covered by the other dedicated sections and include a wide range of topics. These include, but are not limited to, nutritional genomics, gut microbiotal studies, model organism research in areas of agricultural and dairy sciences, comparative studies using rats, mice, zebrafish, etc., statistical genetics, computational modeling studies and reports of model organism databases. Reports on gene annotation catalogs are also welcome. Research can be submitted either as full-length research papers