Biological roles of microRNAs in the control of insulin secretion and action
Sophie Calderari, Malika R. Diawara, Alois Garaud, Dominique Gauguier
Physiological Genomics Published 1 January 2017 Vol. 49 no. 1, 1-10 DOI: 10.1152/physiolgenomics.00079.2016
1Sorbonne Universities, University Pierre & Marie Curie, University Paris Descartes, Sorbonne Paris Cité, INSERM UMR_S 1138, Cordeliers Research Centre, Paris, France; and 2Institut National de la Recherche Agronomique, ENVA, University Paris Saclay, Jouy en Josas, France
Illustration of microRNA (miRNA)-driven gene expression regulation through coexpression patterns of a miRNA and its mRNA targets in different organs. The biological effects of an miRNA present in an organ is dependent on conserved and tissue-specific expression of its target genes (a, b, c) (A) and can be altered by adaptive expression of these genes to a stimulus (B). Genetic polymorphisms in the seed sequence of a target transcript (C) or in the miRNA sequence (D) can alter binding of the miRNA to its target gene and may potentially create novel interactions between the miRNA and other genes (D) and change the biological function of the miRNA. Red boxes indicate that genes are expressed in a given organ, and blue boxes indicate that are not expressed.