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Physiol. Genomics (June 10, 2008). doi:10.1152/physiolgenomics.90254.2008
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Submitted on May 20, 2008
Revised on June 4, 2008
Accepted on June 5, 2008

MicroRNA and cardiac pathologies

Michael V. G. Latronico1, Daniele Catalucci, and Gianluigi Condorelli2*

1 IRCCS MultiMedica
2 University of California San Diego

* To whom correspondence should be addressed. E-mail: gcondorelli{at}ucsd.edu.

MicroRNA has been shown to be essential for correct cardiovascular development and physiology in a number of recent reports. Studies have also started to characterize the link between specific microRNAs and aspects of pathogenesis - such as chamber morphogenesis, conduction, and contraction - and between microRNA expression signatures and pathological cardiac phenotypes - such as hypertrophy, ischemic cardiomyopathy, dilated cardiomyopathy, and aortic stenosis. Congenital anomalies of the heart may also be associated with the dysregulation of specific microRNAs. Here we report on the latest findings.




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