Physiol. Genomics Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiol. Genomics 8: 131-137, 2002. First published January 15, 2002; doi:10.1152/physiolgenomics.00077.2001
1094-8341/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Tables
Right arrow All Versions of this Article:
8/2/131    most recent
00077.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (5)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Saito, S.
Right arrow Articles by Kato, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Saito, S.
Right arrow Articles by Kato, K.
Received 4 September 2001; accepted in final form 2 January 2002.
Physiological Genomics 8:131-137 (2002)
1094-8341/02 $5.00 © 2002 American Physiological Society

Comparison of gene expression profiling during postnatal development of mouse dentate gyrus and cerebellum

Sakae Saito1,2, Ryo Matoba1,2, Noriko Ueno1, Kenichi Matsubara1,2 and Kikuya Kato1,2

1 Taisho Laboratory of Functional Genomics, Nara Institute of Science and Technology
2 Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, 8916-5 Takayama, Ikoma, Nara, 630-0101, Japan

Both the dentate gyrus of the hippocampus and the cerebellar cortex consist mainly of granule cells and develop postnatally. The granule cells in both tissues are presumed to be similar. Changes in gene expression were analyzed during the postnatal development of the dentate gyrus. Altogether, expression patterns of 1,937 genes were determined by adaptor-tagged competitive PCR. More than 90% of the genes belong to groups characterized by elevated expression either at earlier or later stages of development. A majority of the genes expressed showed marked changes during the developmental process, but there was little correlation between gene function and expression, unlike that observed during mouse postnatal cerebellar development. Despite anatomical and physiological similarities between these two processes, the gene expression profiles are completely different.

adaptor-tagged competitive polymerase chain reaction; cluster analysis




This article has been cited by other articles:


Home page
 DevelopmentHome page
J. Lu, Y. Wu, N. Sousa, and O. F. X. Almeida
SMAD pathway mediation of BDNF and TGF{beta}2 regulation of proliferation and differentiation of hippocampal granule neurons
Development, July 15, 2005; 132(14): 3231 - 3242.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online