HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 32/3/401    most recent 00241.2007v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lightfoot, J. T. Articles by Leamy, L. J. Search for Related Content PubMed PubMed Citation Articles by Lightfoot, J. T. Articles by Leamy, L. J.

Quantitative trait loci for physical activity traits in mice

¹ Department of Kinesiology, University of North Carolina, Charlotte
² Department of Biology, University of North Carolina, Charlotte
³ Departments of Nutrition and Cell and Molecular Physiology and Carolina Center for Genome Science, University of North Carolina, Chapel Hill
⁴ Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Durham, North Carolina

The genomic locations and identities of the genes that regulate voluntary physical activity are presently unknown. The purpose of this study was to search for quantitative trait loci (QTL) that are linked with daily mouse running wheel distance, duration, and speed of exercise. F₂ animals (n = 310) derived from high active C57L/J and low active C3H/HeJ inbred strains were phenotyped for 21 days. After phenotyping, genotyping with a fully informative single-nucleotide polymorphism panel with an average intermarker interval of 13.7 cM was used. On all three activity indexes, sex and strain were significant factors, with the F₂ animals similar to the high active C57L/J mice in both daily exercise distance and duration of exercise. In the F₂ cohort, female mice ran significantly farther, longer, and faster than male mice. QTL analysis revealed no sex-specific QTL but at the 5% experimentwise significance level did identify one QTL for duration, one QTL for distance, and two QTL for speed. The QTL for duration (DUR13.1) and distance (DIST13.1) colocalized with the QTL for speed (SPD13.1). Each of these QTL accounted for 6% of the phenotypic variance, whereas SPD9.1 (chromosome 9, 7 cM) accounted for 11.3% of the phenotypic variation. DUR13.1, DIST13.1, SPD13.1, and SPD9.1 were subsequently replicated by haplotype association mapping. The results of this study suggest a genetic basis of voluntary activity in mice and provide a foundation for future candidate gene studies.

genetics; locomotion; linkage mapping

This article has been cited by other articles:

				L. J. Leamy, D. Pomp, and J. T. Lightfoot An Epistatic Genetic Basis for Physical Activity Traits in Mice J. Hered., June 5, 2008; (2008) esn045v1. [Abstract] [Full Text] [PDF]

				J. T. Lightfoot Commentary on Viewpoint: Perspective on the future use of genomics in exercise prescription J Appl Physiol, April 1, 2008; 104(4): 1249 - 1249. [Full Text] [PDF]