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Physiol. Genomics 25: 286-293, 2006. First published January 24, 2006; doi:10.1152/physiolgenomics.00135.2005
1094-8341/06 $8.00
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Received 10 June 2005; accepted in final form 17 January 2006.
Physiological Genomics 25:286-293 (2006)
1094-8341/06 $8.00 © 2006 American Physiological Society

Linkage analysis of neointimal hyperplasia and vascular wall transformation after balloon angioplasty

Andrea L. Nestor1,3, George T. Cicila2, Seth E. Karol1,3, Kay M. Langenderfer1,3, Stacy L. Hollopeter1,3 and David C. Allison1,2,3

1 Departments of Surgery, Pharmacology, Metabolism, and Cardiovascular Science, Medical University of Ohio, Toledo, Ohio
2 Physiology, Pharmacology, Metabolism, and Cardiovascular Science, Medical University of Ohio, Toledo, Ohio
3 Medical University of Ohio Microscopy Imaging Center, Medical University of Ohio, Toledo, Ohio

Neointimal hyperplasia (NIH), a result of vascular injury, is due to the migration and proliferation of smooth muscle cells through the media and internal elastic lamina leading to vascular occlusion. We used a rat model to find the genetic regions controlling NIH after endothelial denudation in two divergent inbred strains of rats. The Brown Norway (BN) and spontaneously hypertensive rat (SHR) strains have a 2.5-fold difference in injury-induced NIH. A population of 301 F2 (SHR x BN) rats underwent a standard vascular injury followed by phenotyping 8 wk after injury to identify quantitative trait loci (QTL) responsible for this strain difference. Interval mapping identified two %NIH QTL on rat chromosomes 3 and 6 [logarithm of odds (LOD) scores 2.5, 2.2] and QTL for other injured vascular wall changes on rat chromosomes 3, 4, and 15 (LOD scores 2.0–4.6). Also, QTL for control vessel media width (MW) and media area (MA) were found on chromosome 6 with LOD scores of 2.3 and 2.5, suggesting that linkage exists between these control vessel parameters and NIH production. These results represent the first genetic analysis for the identification of NIH QTL and QTL associated with the vascular injury response.

quantitative trait loci; restenosis; vascular injury; inbred strains; Brown Norway rat; spontaneously hypertensive rat






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