Physiol. Genomics AJP: Regulatory, Integrative and Comparative Physiology
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Physiol. Genomics 25: 1-8, 2006. First published January 3, 2006; doi:10.1152/physiolgenomics.00166.2005
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Received 11 July 2005; accepted in final form 29 November 2005.
Physiological Genomics 25:1-8 (2006)
American Physiological Society © 2006 American Physiological Society

Perspectives

From sequences to a functional unit

Ashwin Sivakumar , Christopher Wilton and Liisa Holm

Institute of Biotechnology and Department of Genetics, University of Helsinki, Helsinki, Finland

Functional insights at the gene product level would help the drug discovery industry to effectively tap targets for therapeutics and biomedical applications. A complete functional unit can be multidomain, and it is the co-occurrence and interaction of these multiple domains that determine the function and functional diversity of their gene products. With at least 10% of genes from complete genomes existing in fused form, identifying gene fusion events helps us categorize the protein universe into distinct functional units with only sequence information.

drug discovery; component proteins; composite proteins; superfamily; functional annotation; family; subfamily; gene fusion




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[Abstract] [Full Text] [PDF]


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