Physiol. Genomics AJP: Regulatory, Integrative and Comparative Physiology
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Physiol. Genomics 20: 15-20, 2004. First published October 19, 2004; doi:10.1152/physiolgenomics.00197.2003
1094-8341/04 $5.00
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Received 24 November 2003; accepted in final form 20 September 2004.
Physiological Genomics 20:15-20 (2004)
1094-8341/02 $5.00 © 2004 American Physiological Society

Phenotypic variation in cardiovascular responses to acute hypoxic and hypercapnic exposure in mice

Matthew J. Campen 1, Yugo Tagaito 2, Jianguo Li 1, Alexander Balbir 1, Clarke G. Tankersley 1, Phillip Smith 1, Alan Schwartz 1 and Christopher P. O’Donnell 3

1 Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland
2 Department of Anesthesiology, Chiba University School of Medicine, Japan
3 Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

The impact of genetic variation on cardiovascular responses to hypoxia and hypercapnia is not well understood. Therefore, we determined the acute changes in systemic arterial blood pressure (PSA) and heart rate (HR) in seven strains of commonly used inbred mice exposed to acute periods of hypoxia (10% O2), hypercapnia (5% CO2), and hypoxia/hypercapnia (10% O2 + 5% CO2) during wakefulness. Hypercapnia induced an essentially homogeneous response across strains, with PSA maintained at or slightly above baseline and with HR exhibiting a typical baroreceptor-mediated bradycardia. In contrast, exposure to hypoxia elicited a marked heterogeneity in cardiovascular responses between strains. The change in PSA during hypoxia ranged from maintenance of normotension in the FVB/J strain to profound hypotension of ~30 mmHg in the DBA/2J strain. HR responses were highly variable between strains during hypoxia, and with the exception of the DBA/2J strain that exhibited significant bradyarrhythmias and consequent hypotension, the HR responses were unrelated to changes in PSA. The PSA response to combined hypoxia/hypercapnia represented a balance of the hypertension of hypercapnia and the hypotension of hypoxia in six of the seven strains. In the FVB/J strain, combined hypoxia/hypercapnia produced a hypertensive response that was greater than that of hypercapnia alone. These results suggest that genetic background affects the cardiovascular response to hypoxia, but not hypercapnia.

ventilation; hypotension; apnea; hemodynamics; arrhythmia




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