HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 16/3/309    most recent 00024.2003v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Dos Santos, C. Articles by Bougnères, P. Search for Related Content PubMed PubMed Citation Articles by Dos Santos, C. Articles by Bougnères, P.

INS VNTR is a QTL for the insulin response to oral glucose in obese children

¹ Department of Pediatric Endocrinology and Unité 561 Institut National de la Santé et de la Recherche Médicale, Hôpital Saint Vincent de Paul, René Descartes University, 75014 Paris, France
² Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21025

Dos Santos, Christine, Daniele Fallin, Catherine Le Stunff, Sophie LeFur, and Pierre Bougnères. INS VNTR is a QTL for the insulin response to oral glucose in obese children. Physiol Genomics 16: 309-313, 2004. First published December 2, 2003; 10.1152/ physiolgenomics.00024.2003.— We performed a genotype-phenotype association study to examine whether the insulin VNTR (INS VNTR) polymorphism located in the insulin gene promoter was associated with changes in insulin response to oral glucose. Two classes of INS VNTR alleles are observed in Caucasians, the "short" class I and the "long" class III. Plasma insulin and glucose concentrations and indices of insulin secretion (IGI) and sensitivity (ISI) were measured using an oral glucose tolerance test (OGTT) in 387 obese children aged 12 ± 0.1 yr with a mean body mass index (BMI) of 30.6 kg/m² (161% of the normal mean). During OGTT, plasma insulin and IGI were 20–30% higher in I/I obese children vs. III carriers (P < 0.01). A general linear model adjusting for age, sex, and puberty was also used to evaluate the influence of the VNTR genotype on the BMI-IGI (P = 0.07) and the BMI-ISI (P < 0.006) relationships. The INS VNTR can therefore be considered a quantitative trait locus influencing glucose-stimulated insulin physiology in obese juveniles.

insulin gene; variable number of tandem repeats; quantitative trait locus; insulin secretion; obesity

This article has been cited by other articles:

				P. Bougneres, L. Pantalone, A. Linglart, A. Rothenbuhler, and C. Le Stunff Endocrine Manifestations of the Rapid-Onset Obesity with Hypoventilation, Hypothalamic, Autonomic Dysregulation, and Neural Tumor Syndrome in Childhood J. Clin. Endocrinol. Metab., October 1, 2008; 93(10): 3971 - 3980. [Abstract] [Full Text] [PDF]

				L. Marchand and C. Polychronakos Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene With Diabetes Diabetes, March 1, 2007; 56(3): 709 - 713. [Abstract] [Full Text] [PDF]

				H. Zhou, C. M. Evock-Clover, J. P. McMurtry, C. M. Ashwell, and S. J. Lamont Genome-Wide Linkage Analysis to Identify Chromosomal Regions Affecting Phenotypic Traits in the Chicken. IV. Metabolic Traits Poult. Sci., February 1, 2007; 86(2): 267 - 276. [Abstract] [Full Text] [PDF]

				P. Bougneres Genotypic and phenotypic complexity at the insulin variable number of tandem repeats locus. J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4246 - 4249. [Full Text] [PDF]

				N. Santoro, G. Cirillo, A. Amato, C. Luongo, P. Raimondo, A. D'Aniello, L. Perrone, and E. Miraglia del Giudice Insulin Gene Variable Number of Tandem Repeats (INS VNTR) Genotype and Metabolic Syndrome in Childhood Obesity J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4641 - 4644. [Abstract] [Full Text] [PDF]

				B. Heude, C. J. Petry, the Avon Longitudinal Study of Parents Children (A, M. Pembrey, D. B. Dunger, and K. K. Ong The Insulin Gene Variable Number of Tandem Repeat: Associations and Interactions with Childhood Body Fat Mass and Insulin Secretion in Normal Children J. Clin. Endocrinol. Metab., July 1, 2006; 91(7): 2770 - 2775. [Abstract] [Full Text] [PDF]

				S. Le Fur, C. Auffray, F. Letourneur, C. Cruaud, C. Le Stunff, and P. Bougneres Heterogeneity of class I INS VNTR allele association with insulin secretion in obese children Physiol Genomics, May 16, 2006; 25(3): 480 - 484. [Abstract] [Full Text] [PDF]

				M. Liang and B. Ventura Physiological genomics in PG and beyond: July to September 2005 Physiol Genomics, October 17, 2005; 23(2): 119 - 124. [Full Text] [PDF]