Physiol. Genomics AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiol. Genomics 15: 44-51, 2003. First published July 15, 2003; doi:10.1152/physiolgenomics.00063.2003
1094-8341/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Table
Right arrow All Versions of this Article:
15/1/44    most recent
00063.2003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (17)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Harper, J. M.
Right arrow Articles by Miller, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harper, J. M.
Right arrow Articles by Miller, R. A.
Received 14 April 2003; accepted in final form 13 July 2003.
Physiological Genomics 15:44-51 (2003)
1094-8341/03 $5.00 © 2003 American Physiological Society

Quantitative trait loci for insulin-like growth factor I, leptin, thyroxine, and corticosterone in genetically heterogeneous mice

James M. Harper 1, Andrzej T. Galecki 2,3,4, David T. Burke 5, Stephen L. Pinkosky 1 and Richard A. Miller 1,2,3,4

1 Department of Pathology, University of Michigan School of Medicine, Ann Arbor
2 Geriatrics Center, University of Michigan School of Medicine, Ann Arbor
3 University of Michigan Institute of Gerontology
4 Ann Arbor Department of Veterans Affairs Medical Center
5 Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, Michigan 48109-0940

Genotype information was collected at 87 loci in a group of 1,108 UM-HET3 mice bred as the progeny of [BALB/cJ x C57BL/6J]F1 mothers and [C3H/HeJ x DBA/2J]F1 fathers, for which thyroxine (T4), insulin-like growth factor I (IGF-I), and leptin levels had been measured at 4 and 15 mo of age. The data provided significant evidence for quantitative trait loci (QTL) modulating IGF-I levels on chromosomes 1, 3, 8, 10, and 17; for loci affecting T4 on chromosomes 4, 15, and 17; and for leptin on chromosome 3. Fecal levels of corticosterone at 17 mo of age were influenced by a QTL on chromosome 1. Nine other gene/hormone associations reached a nominal P < 0.01, providing suggestive but not statistical evidence for additional QTL. QTL with an influence on a given hormone were in nearly all cases additive, with little or no evidence for epistasis. Of the 12 strongest QTL, 5 had effects that were age dependent, having more effect in 15-mo-old than in 4-mo-old mice in all but one case; the other QTL had effects that were apparently age-independent. These results show that the genetic controls over late-life hormone levels are complex and dependent on effects of genes that act both early and late in the life course.

epistasis; UM-HET3 mice; late-life hormone levels; age-specific




This article has been cited by other articles:


Home page
 J ANIM SCIHome page
L. A. Kuehn, D. J. Nonneman, J. M. Klindt, and T. H. Wise
Genetic relationships of body composition, serum leptin, and age at puberty in gilts
J Anim Sci, February 1, 2009; 87(2): 477 - 483.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
L. E. Bauman, J. S. Sinsheimer, E. M. Sobel, and K. Lange
Mixed Effects Models for Quantitative Trait Loci Mapping With Inbred Strains
Genetics, November 1, 2008; 180(3): 1743 - 1761.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. L. Chisa and D. T. Burke
Mammalian mRNA Splice-Isoform Selection Is Tightly Controlled
Genetics, March 1, 2007; 175(3): 1079 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
S. M. Clee and A. D. Attie
The Genetic Landscape of Type 2 Diabetes in Mice
Endocr. Rev., February 1, 2007; 28(1): 48 - 83.
[Abstract] [Full Text] [PDF]

Home page
 Poult. Sci.Home page
H. Zhou, C. M. Evock-Clover, J. P. McMurtry, C. M. Ashwell, and S. J. Lamont
Genome-Wide Linkage Analysis to Identify Chromosomal Regions Affecting Phenotypic Traits in the Chicken. IV. Metabolic Traits
Poult. Sci., February 1, 2007; 86(2): 267 - 276.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
L. C. Solberg, A. E. Baum, N. Ahmadiyeh, K. Shimomura, R. Li, F. W. Turek, J. S. Takahashi, G. A. Churchill, and E. E. Redei
Genetic analysis of the stress-responsive adrenocortical axis
Physiol Genomics, November 21, 2006; 27(3): 362 - 369.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
J. M. Harper, S. J. Durkee, R. C. Dysko, S. N. Austad, and R. A. Miller
Genetic modulation of hormone levels and life span in hybrids between laboratory and wild-derived mice.
J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2006; 61(10): 1019 - 1029.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
P. Hanlon, W. A. Lorenz, Z. Shao, J. M. Harper, A. T. Galecki, R. A. Miller, and D. T. Burke
Three-locus and four-locus QTL interactions influence mouse insulin-like growth factor-I
Physiol Genomics, September 14, 2006; 26(1): 46 - 54.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. E. Baum, L. C. Solberg, P. Kopp, N. Ahmadiyeh, G. Churchill, J. S. Takahashi, J. L. Jameson, and E. E. Redei
Quantitative Trait Loci Associated with Elevated Thyroid-Stimulating Hormone in the Wistar-Kyoto Rat
Endocrinology, February 1, 2005; 146(2): 870 - 878.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
R. Lipman, A. Galecki, D. T. Burke, and R. A. Miller
Genetic Loci That Influence Cause of Death in a Heterogeneous Mouse Stock
J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2004; 59(10): B977 - B983.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.