| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Pharmacology, University of California San Diego, La Jolla, California 92093-0636
2 Institute of Biology and Medical Genetics, Charles University, 12800 Prague, Czech Republic
Evidence exists implying multiple blood pressure quantitative trait loci (QTL) on rat chromosome 2. To examine this possibility, four congenic strains and nine substrains were developed with varying size chromosome segments introgressed from the spontaneously hypertensive rat (SHR/lj) and normotensive Wistar-Kyoto rat (WKY/lj) onto the reciprocal genetic background. Cardiovascular phenotyping was conducted with telemetry over extended periods during standard salt (0.7%) and high-salt (8%) diets. Our results are consistent with at least three independent pressor QTL: transfer of SHR/lj alleles to WKY/lj reveals pressor QTL within D2Rat21-D2Rat27 and D2Mgh10-D2Rat62, whereas transfer of WKY/lj D2Rat161-D2Mit8 to SHR/lj reveals a depressor locus. Our results also suggest a depressor QTL in SHR/lj located within D2Rat161-D2Mgh10. Introgressed WKY/lj segments also reveal a heart rate QTL within D2Rat40-D2Rat50 which abolished salt-induced bradycardia, dependent upon adjoining SHR/lj alleles. This study confirms the presence of multiple blood pressure QTL on chromosome 2. Taken together with our other studies, we conclude that rat chromosome 2 is rich in alleles for cardiovascular and behavioral traits and for coordinated coupling between behavior and cardiovascular responses.
hypertension; genetic; salt; SHR; telemetry
This article has been cited by other articles:
|
|
 |
|
  J. Flint and T. F.C. Mackay Genetic architecture of quantitative traits in mice, flies, and humans Genome Res., May 1, 2009; 19(5): 723 - 733. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Packard, Y. Saad, W. T. Gunning, S. Gupta, J. Shapiro, and M. R. Garrett Investigating the effect of genetic background on proteinuria and renal injury using two hypertensive strains Am J Physiol Renal Physiol, April 1, 2009; 296(4): F839 - F846. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Aneas, M. V. Rodrigues, B. A. Pauletti, G. J. J. Silva, R. Carmona, L. Cardoso, A. E. Kwitek, H. J. Jacob, J. M. P. Soler, and J. E. Krieger Congenic strains provide evidence that four mapped loci in chromosomes 2, 4, and 16 influence hypertension in the SHR Physiol Genomics, March 3, 2009; 37(1): 52 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Sedlacek, K. Stark, S. R. Cunha, A. Pfeufer, S. Weber, I. Berger, S. Perz, S. Kaab, H.-E. Wichmann, P. J. Mohler, et al. Common Genetic Variants in ANK2 Modulate QT Interval: Results From the KORA Study Circ Cardiovasc Genet, December 1, 2008; 1(2): 93 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Le Scouarnec, N. Bhasin, C. Vieyres, T. J. Hund, S. R. Cunha, O. Koval, C. Marionneau, B. Chen, Y. Wu, S. Demolombe, et al. Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease PNAS, October 7, 2008; 105(40): 15617 - 15622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Y. Deng Genetic basis of polygenic hypertension Hum. Mol. Genet., October 15, 2007; 16(R2): R195 - R202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Mott Finding the molecular basis of complex genetic variation in humans and mice Phil Trans R Soc B, March 29, 2006; 361(1467): 393 - 401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Charron, R. Lambert, V. Eliopoulos, C. Duong, A. Menard, J. Roy, and A. Y. Deng A loss of genome buffering capacity of Dahl salt-sensitive model to modulate blood pressure as a cause of hypertension Hum. Mol. Genet., December 15, 2005; 14(24): 3877 - 3884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Eliopoulos, J. Dutil, Y. Deng, M. Grondin, and A. Y. Deng Severe hypertension caused by alleles from normotensive Lewis for a quantitative trait locus on chromosome 2 Physiol Genomics, June 16, 2005; 22(1): 70 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Dutil, V. Eliopoulos, E.-L. Marchand, A. M. Devlin, J. Tremblay, K. Prithiviraj, P. Hamet, A. Migneault, D. deBlois, and A. Y. Deng A quantitative trait locus for aortic smooth muscle cell number acting independently of blood pressure: implicating the angiotensin receptor AT1B gene as a candidate Physiol Genomics, May 11, 2005; 21(3): 362 - 369. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Dutil, V. Eliopoulos, J. Tremblay, P. Hamet, S. Charron, and A. Y. Deng Multiple Quantitative Trait Loci for Blood Pressure Interacting Epistatically and Additively on Dahl Rat Chromosome 2 Hypertension, April 1, 2005; 45(4): 557 - 564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Grondin, V. Eliopoulos, R. Lambert, Y. Deng, A. Ariyarajah, M. Moujahidine, J. Dutil, S. Charron, and A. Y. Deng Complete and overlapping congenics proving the existence of a quantitative trait locus for blood pressure on Dahl rat chromosome 17 Physiol Genomics, March 21, 2005; 21(1): 112 - 116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Martin, A. G. Comuzzie, G. E. Sonnenberg, J. Myklebust, R. James, J. Marks, J. Blangero, and A. H. Kissebah Major Quantitative Trait Locus for Resting Heart Rate Maps to a Region on Chromosome 4 Hypertension, May 1, 2004; 43(5): 1146 - 1151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Mein, M. J. Caulfield, R. J. Dobson, and P. B. Munroe Genetics of essential hypertension Hum. Mol. Genet., April 1, 2004; 13(90001): R169 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Printz, M. Jirout, R. Jaworski, A. Alemayehu, and V. Kren Genetic Models in Applied Physiology: Invited Review: HXB/BXH rat recombinant inbred strain platform: a newly enhanced tool for cardiovascular, behavioral, and developmental genetics and genomics J Appl Physiol, June 1, 2003; 94(6): 2510 - 2522. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
