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Physiol. Genomics 10: 199-210, 2002. First published July 23, 2002; doi:10.1152/physiolgenomics.00065.2002
1094-8341/02 $5.00
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Received 28 May 2002; accepted in final form 18 July 2002.
Physiological Genomics 10:199-210 (2002)
1094-8341/02 $5.00 © 2002 American Physiological Society

Reciprocal rat chromosome 2 congenic strains reveal contrasting blood pressure and heart rate QTL

Adamu Alemayehu1, Laura Breen1, Drahomira Krenova, 2 and Morton P. Printz, 1

1 Department of Pharmacology, University of California San Diego, La Jolla, California 92093-0636
2 Institute of Biology and Medical Genetics, Charles University, 12800 Prague, Czech Republic

Evidence exists implying multiple blood pressure quantitative trait loci (QTL) on rat chromosome 2. To examine this possibility, four congenic strains and nine substrains were developed with varying size chromosome segments introgressed from the spontaneously hypertensive rat (SHR/lj) and normotensive Wistar-Kyoto rat (WKY/lj) onto the reciprocal genetic background. Cardiovascular phenotyping was conducted with telemetry over extended periods during standard salt (0.7%) and high-salt (8%) diets. Our results are consistent with at least three independent pressor QTL: transfer of SHR/lj alleles to WKY/lj reveals pressor QTL within D2Rat21-D2Rat27 and D2Mgh10-D2Rat62, whereas transfer of WKY/lj D2Rat161-D2Mit8 to SHR/lj reveals a depressor locus. Our results also suggest a depressor QTL in SHR/lj located within D2Rat161-D2Mgh10. Introgressed WKY/lj segments also reveal a heart rate QTL within D2Rat40-D2Rat50 which abolished salt-induced bradycardia, dependent upon adjoining SHR/lj alleles. This study confirms the presence of multiple blood pressure QTL on chromosome 2. Taken together with our other studies, we conclude that rat chromosome 2 is rich in alleles for cardiovascular and behavioral traits and for coordinated coupling between behavior and cardiovascular responses.

hypertension; genetic; salt; SHR; telemetry




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