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Physiol. Genomics (April 26, 2005). doi:10.1152/physiolgenomics.00243.2004 Free Article
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Submitted on October 15, 2004
Accepted on April 18, 2005

Influence of Genetic Background on Daily Running Wheel Activity Differs with Aging

Michael J Turner1*, Steven R Kleeberger2, and J. Timothy Lightfoot1

1 Department of Kinesiology, University of North Carolina Charlotte, Charlotte, NC, USA
2 Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Durham, NC, USA

* To whom correspondence should be addressed. E-mail: miturner{at}uncc.edu.

In humans, physical activity declines with age. We tested the hypothesis that genetic background and age interact to determine daily wheel-running physical activity patterns in mice. Five female mice from ten inbred strains (A/J, AKR/J, Balb/cJ, CBA/J, C3H/HeJ, C3Heb/FeJ, C57Bl/6J, C57L/J, DBA/2J and SWR/J) were studied for 26 weeks starting at 10 weeks of age. All mice were housed in separate cages, each with a running wheel and magnetic sensor. Throughout the 26-week period, age-related change in daily duration (p < 0.0001), daily distance (p < 0.0001), and average velocity (p = 0.0003) differed between the inbred strains. Unlike the other strains, SWR/J mice increased their running wheel activity throughout the 6-month time period. Broad-sense heritability estimations for the strains across the 26-week period ranged between 0.410 and 0.855 for the three physical activity phenotypes. Further, the broad-sense heritability estimates for daily running wheel distance differed across time and suggested an interaction between genetic background and age on physical activity in these inbred mice.




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