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1 Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH, USA
2 Department of Molecular Genetics, Microbiology and Biochemistry, University of Cincinnati College of Medicine, Cincinnati, OH, USA
3 Division of Pediatric Informatics, Children's Hospital Research Foundation, Cincinnati, OH, USA
4 Division of Pathology, Children's Hospital Research Foundation, Cincinnati, OH, USA
5 Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA
6 Division of Molecular and Developmental Biology, Children's Hospital Research Foundation, Cincinnati, OH, USA
7 Department of Pharmacology and Cellular Biophysics, university of Cincinnati College of Medicine, Cincinnati, OH, USA
8 Division of Pediatric Informatics, Children's Hospital Research Foundation, Cincinnati, OH, USA; Division of Molecular and Developmental Biology, Children's Hospital Research Foundation, Cincinnati, OH, USA
* To whom correspondence should be addressed. E-mail: jianhua.zhang{at}uc.edu.
To understand genomic commitment to nervous system differentiation and function in relation to peripheral tissues, we used microarrays to generate a nervous system-specific gene expression database. Gene expression profiles of 10 different adult nervous tissues were compared to that of 72 other tissues. We identified 1361 genes that are statistically highly expressed in the nervous system compared to other organs, and 600 genes expressed at least 3- fold higher in one or more regions of the nervous system compared to other organs. We found that 381 genes within the 1361 genes are shared by the 600 genes expressed at least 3- fold in one or more regions of the nervous system compared to other organs. Diverse functional categories were present in the 381 genes, including high representations of genes involved in intracellular signaling, cytoskeleton structure and function, enzymes, RNA metabolism and transcription, membrane proteins, as well as cell differentiation, death, proliferation and division. We searched existing public sites and identified 110 known genes related to mental retardation, neurological disease and neurodegeneration. Twenty-one genes out of the 381 were within the 110 gene list, while the expected number from the 381 gene list to overlap with the 110 gene list is only 5. These 381 genes thus provide a candidate set for further analyses in neurological and psychiatric disease studies. Together, our data indicate the power of profiling an individual biologic system in a multi-system context to gain insight into the genomic basis of its structure and function.
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