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1 Pathology & Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA; Physiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA; Membrane Biology Laboratory, West Los Angeles VA Medical Center, Los Angeles, CA, USA
2 Physiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA; Membrane Biology Laboratory, West Los Angeles VA Medical Center, Los Angeles, CA, USA
3 Physiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA; Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA; Membrane Biology Laboratory, West Los Angeles VA Medical Center, Los Angeles, CA, USA
* To whom correspondence should be addressed. E-mail: nilslam{at}ucla.edu.
Genomic microarray analysis of genes specifically expressed in a pure cell isolate from a hetero-cellular organ identified the likely K efflux channel associated with the gastric H,K ATPase. The function of this channel is to supply K to the luminal surface of the pump to allow H for K exchange. KCNQ1-KCNE2 was the most highly expressed and significantly enriched member of the large variety of K channels expressed in the gastric epithelium. The function of this K channel in acid secretion was then shown by inhibition of secretion in isolated gastric glands with specific KCNQ inhibitors and by the co-localization of the channel with the H,K-ATPase in the secretory canaliculus of the parietal cell. KCNQ1-KCNE2 appears to be the K efflux channel that is essential for gastric acid secretion.
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