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1 Institut fuer Genetik, Forschungszentrum Karlsruhe, Karlsruhe, Germany
2 Institut fuer Pathologie, Universitaet Bonn, Bonn, Germany
3 Institut fuer Angewandte Informatik, Forschungszentrum Karlsruhe, Karlsruhe, Germany
* To whom correspondence should be addressed. E-mail: michael.pankratz{at}itg.fzk.de.
We have monitored global changes in gene expression in mouse liver in response to fasting and sugar fed conditions using high density microarrays. From approximately 20,000 different genes, the significantly regulated ones were grouped into specific signaling and metabolic pathways. Striking changes in lipid signaling cascade, insulin and DHEA hormonal pathways, urea cycle and S-adenosylmethionine based methyl transfer systems, and cell apoptosis regulators were observed. Since these pathways have been implicated to play a role in the aging process, and since we observe significant overlap of genes regulated upon starvation with those regulated upon caloric restriction, our analysis suggests that starvation may elicit a stress response which is also elicited during caloric restriction. Therefore, many of the signaling and metabolic components regulated during fasting may be the same as those which mediate caloric restriction dependent lifespan extension.
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