Physiol. Genomics AJP: Regulatory, Integrative and Comparative Physiology
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Physiol. Genomics (January 3, 2006). doi:10.1152/physiolgenomics.00166.2005
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Submitted on July 11, 2005
Accepted on November 29, 2005

From sequences to a functional unit

Ashwin Sivakumar1*, Christopher Wilton2, and Liisa Holm1

1 Department of Genetics, Institute of Biotechnology, Helsinki, Finland;
2 Department of Genetics, Institute of Biotechnology, Helsinki, Finland

* To whom correspondence should be addressed. E-mail: ashwin.sivakumar{at}helsinki.fi.

Functional insights at the gene product level would help the drug discovery industry to effectively tap targets for therapeutics and biomedical applications. A complete functional unit can be multi-domain, and it is the co-occurrence and interaction of these multiple domains that determines the function and functional diversity of their gene products. With at least 10% of genes from complete genomes existing in fused form, identifying gene fusion events helps us categorizing the protein universe into distinct functional units using only sequence information.




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A. Heger, S. Mallick, C. Wilton, and L. Holm
The global trace graph, a novel paradigm for searching protein sequence databases
Bioinformatics, September 15, 2007; 23(18): 2361 - 2367.
[Abstract] [Full Text] [PDF]


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