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Physiol. Genomics (December 9, 2003). doi:10.1152/physiolgenomics.00162.2003
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Submitted on September 25, 2003
Accepted on December 6, 2003

X-linked loci influence spatial navigation performance in Dahl rats

Nelson Ruiz-Opazo1* and John Tonkiss2

1 Department of Medicine, Section of Molecular Medicine, Boston University School of Medicine, Boston, MA, USA
2 Center for Behavioral Development and Mental Retardation, Boston University School of Medicine, Boston, MA, USA

* To whom correspondence should be addressed. E-mail: nruizo{at}bu.edu.

Elucidation of natural genetic variations underlying strain or individual differences in cognitive function has remained elusive. Here we report the identification of two genetic loci that influence spatial navigation in Dahl rats. In the Morris water maze test, Dahl R rats exhibited efficient spatial navigation, whereas Dahl S rats displayed poor spatial navigation (accuracy). Analysis of F1 male progeny of reciprocal crosses between Dahl S and Dahl R strains implicated the X chromosome with the impairment in spatial navigation observed in Dahl S rats. Quantitative trait locus (QTL) analysis of an (RXS) F2 male population phenotyped for spatial navigation detected two QTLs on chromosome X influencing spatial navigation performance. One QTL (N{alpha}v-1, centered at DXR{alpha}t21, significant for linkage) influenced acquisition performance without affecting spatial accuracy performance and the second QTL (N{alpha}v-2, centered at DXR{alpha}t25, significant for linkage) affected spatial accuracy performance with no detectable effect on acquisition performance. Our results demonstrate X-linkage of spatial navigation performance in Dahl rats and provide evidence for the existence of independent genetic determinants for defined behavioral components of spatial navigation.




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N. Ruiz-Opazo and J. Tonkiss
Genome-wide scan for quantitative trait loci influencing spatial navigation and social recognition memory in Dahl rats
Physiol Genomics, September 14, 2006; 26(2): 145 - 151.
[Abstract] [Full Text] [PDF]


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