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1 National Institute of Advanced Industrial Science and Technology (AIST), Computational Biology Research Center (CBRC), 2-41-6 Aomi, Koto-ku, Tokyo, Japan
2 RIKEN Yokohama Institute, Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Japan
3 The University of Tokyo, Department of Biotechnology, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, Japan
* To whom correspondence should be addressed. E-mail: takahashi-k{at}aist.go.jp.
We applied a method based on Akaike's Information Criterion (AIC) to detect genes whose expression profile is considerably different in some tissue(s) than in others. Such observations are detected as outliers and the method we used was originally developed to detect outlier(s). The main advantage of the method is that objective decisions are possible because the procedure is independent of a significance level. We applied the method to 48 expression ratios corresponding to various tissues in each of 14,610 clones obtained from the READ database (http://read.gsc.riken.go.jp). As a result, for several tissues (e.g. muscle-, heart-, and tongue tissues that contain similar cell types) we objectively obtained specific clones without any "thresholding". Our study demonstrates the feasibility of the method for detecting tissue-specific gene expression patterns.
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