| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA
* To whom correspondence should be addressed. E-mail: dmattson{at}mcw.edu.
Experiments examined the influence of diet and genetics on hypertension and renal disease in inbred Dahl salt sensitive (SS/Mcw) rats and consomic rats in which chromosomes 16 (SS.BN16) or 18 (SS.BN18) of the normotensive Brown Norway rat were inserted into the genetic background of the SS/Mcw. Dahl SS/Mcw breeders and offspring were randomly placed on a purified AIN-76A diet or a grain-based diet and male offspring were screened for cardiovascular and renal phenotypes following 3 weeks on a 4.0% NaCl diet. High salt arterial blood pressure (162±5 mmHg, n=10), urinary protein excretion (147±16 mg/day, n=14), and albumin excretion (72±9 mg/day, n=14) were significantly elevated in the Dahl SS/Mcw maintained on the purified diet in comparison to rats fed the grain-based diet. Rats fed the purified diet also exhibited significantly more renal glomerular and tubular damage than rats fed the grain diet. Moreover, feeding the purified diet to the parents led to a significant increase in blood pressure in the offspring, regardless of offspring diet. Similar dietary effects were observed in SS.BN16 and SS.BN18 rats. In rats fed the purified diet, substitution of chromosomes 16 or 18 led to a significant decrease in arterial blood pressure, albumin excretion, and protein excretion in comparison to the SS/Mcw. Chromosomal substitution did not, however, affect albumin or protein excretion in the consomic rats in comparison to the SS/Mcw when the rats were maintained on the grain diet. These data demonstrate a significant influence of diet composition on salt-induced hypertension and renal disease in the Dahl SS/Mcw rat.
This article has been cited by other articles:
|
|
 |
|
  N. W. Rajapakse, C. De Miguel, S. Das, and D. L. Mattson Exogenous L-Arginine Ameliorates Angiotensin II-Induced Hypertension and Renal Damage in Rats Hypertension, December 1, 2008; 52(6): 1084 - 1090. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Mattson, M. R. Dwinell, A. S. Greene, A. E. Kwitek, R. J. Roman, H. J. Jacob, and A. W. Cowley Jr. Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease Am J Physiol Renal Physiol, September 1, 2008; 295(3): F837 - F842. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Mori, A. Polichnowski, P. Glocka, M. Kaldunski, Y. Ohsaki, M. Liang, and A. W. Cowley Jr. High Perfusion Pressure Accelerates Renal Injury in Salt-Sensitive Hypertension J. Am. Soc. Nephrol., August 1, 2008; 19(8): 1472 - 1482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Mattson, M. R. Dwinell, A. S. Greene, A. E. Kwitek, R. J. Roman, A. W. Cowley Jr., and H. J. Jacob Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats Am J Physiol Renal Physiol, December 1, 2007; 293(6): F1905 - F1914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Y. Deng Genetic basis of polygenic hypertension Hum. Mol. Genet., October 15, 2007; 16(R2): R195 - R202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Y. Deng Positional Cloning of Quantitative Trait Loci for Blood Pressure: How Close Are We?: A Critical Perspective Hypertension, April 1, 2007; 49(4): 740 - 747. [Full Text] [PDF]
|
|
|
|
|
|
D. L. Mattson, L. James, E. A. Berdan, and C. J. Meister Immune Suppression Attenuates Hypertension and Renal Disease in the Dahl Salt-Sensitive Rat Hypertension, July 1, 2006; 48(1): 149 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Roman, K. M. Hoagland, B. Lopez, A. E. Kwitek, M. R. Garrett, J. P. Rapp, J. Lazar, H. J. Jacob, and A. Sarkis Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1463 - F1471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Lopez, R. P. Ryan, C. Moreno, A. Sarkis, J. Lazar, A. P. Provoost, H. J. Jacob, and R. J. Roman Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in fawn-hooded hypertensive rats Am J Physiol Renal Physiol, May 1, 2006; 290(5): F1213 - F1221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Charron, R. Lambert, V. Eliopoulos, C. Duong, A. Menard, J. Roy, and A. Y. Deng A loss of genome buffering capacity of Dahl salt-sensitive model to modulate blood pressure as a cause of hypertension Hum. Mol. Genet., December 15, 2005; 14(24): 3877 - 3884. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Liang and B. Ventura Physiological genomics in PG and beyond: October to December 2005 Physiol Genomics, December 14, 2005; 24(1): 1 - 3. [Full Text] [PDF]
|
|
|
|
|
|
D. L. Mattson, M. P. Kunert, R. J. Roman, H. J. Jacob, and A. W. Cowley Jr. Substitution of chromosome 1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive rat Am J Physiol Renal Physiol, May 1, 2005; 288(5): F1015 - F1022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Mattson, C. J. Meister, and M. L. Marcelle Dietary Protein Source Determines the Degree of Hypertension and Renal Disease in the Dahl Salt-Sensitive Rat Hypertension, April 1, 2005; 45(4): 736 - 741. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
