Physiol. Genomics Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Physiol. Genomics (November 5, 2002). doi:10.1152/physiolgenomics.00121.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
12/1/61    most recent
00121.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Boutin-Ganache, I.
Right arrow Articles by Deschepper, C. F
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Boutin-Ganache, I.
Right arrow Articles by Deschepper, C. F

Articles in PresS, published online ahead of print November 5, 2002
Physiol Genomics, 10.1152/physiolgenomics.00121.2002
Submitted on September 19, 2002
Accepted on October 29, 2002

Distinct gene-gender interactions regulate adult rat cardiomyocyte width and length independently from one another

Isabelle Boutin-Ganache1, Sylvie Picard1, and Christian F Deschepper1*

1 Experimental Cardiovascular Biology, IRCM, Montreal, QC, Canada

* To whom correspondence should be addressed. E-mail: deschec{at}ircm.qc.ca.

WKY and WKHA are 2 genetically-related inbred strains of rats that are both normotensive yet exhibit differences in left ventricular mass (LVM). We had shown previously that cardiomyocytes from male WKHA are wider than that of male WKY, and that there was genetic linkage between LVM and a locus on chromosome 5 (RNO5) in the male progeny of a F2 WKHA/WKY cross. We show here that cardiomyocyte width is linked to the same RNO5 locus in male reciprocal congenic rats derived from WKHA and WKY. Contrary to males, we found no genetic linkage between LVM and the RNO5 locus in female rats. However, ventricular hypertrophy in females might be of a different nature, because cardiomyocytes from female WKHA were shorter than their WKY counterparts (with no difference in width). The RNO5 locus contains that of the Natriuretic Peptide Precursor A (Nppa) gene. In male congenic rats, changes in cardiomyocyte width always correlated with reciprocal changes in the LV concentration of atrial natriuretic factor (ANF, i.e. the peptide product of Nppa). Taken together with other functional data, the small size of the RNO5 locus (~63 cR) increased the likelihood that both cardiomyocyte width and LV ANF concentration could be linked to only one gene (possibly Nppa) in male rats. Moreover, our results support the notion that genes and gender interact to regulate cardiomyocyte width and length independently from one another.




This article has been cited by other articles:


Home page
 Physiol. GenomicsHome page
B. Llamas, S. Belanger, S. Picard, and C. F. Deschepper
Cardiac mass and cardiomyocyte size are governed by different genetic loci on either autosomes or chromosome Y in recombinant inbred mice
Physiol Genomics, October 19, 2007; 31(2): 176 - 182.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
B. M. Palmer, Z. Chen, R. R. Lachapelle, E. D. Hendley, and M. M. LeWinter
Cardiomyocyte function associated with hyperactivity and/or hypertension in genetic models of LV hypertrophy
Am J Physiol Heart Circ Physiol, January 1, 2006; 290(1): H463 - H473.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
E. Souzeau, B. Llamas, S. Belanger, S. Picard, and C. F. Deschepper
A Genetic Locus Accentuates the Effect of Volume Overload on Adverse Left Ventricular Remodeling in Male and Female Rats
Hypertension, January 1, 2006; 47(1): 128 - 133.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Zahabi, S. Picard, N. Fortin, T. L. Reudelhuber, and C. F. Deschepper
Expression of Constitutively Active Guanylate Cyclase in Cardiomyocytes Inhibits the Hypertrophic Effects of Isoproterenol and Aortic Constriction on Mouse Hearts
J. Biol. Chem., November 28, 2003; 278(48): 47694 - 47699.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2002 by the American Physiological Society.