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Physiol. Genomics (November 5, 2002). doi:10.1152/physiolgenomics.00121.2002
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Articles in PresS, published online ahead of print November 5, 2002
Physiol Genomics, 10.1152/physiolgenomics.00121.2002
Submitted on September 19, 2002
Accepted on October 29, 2002

Distinct gene-gender interactions regulate adult rat cardiomyocyte width and length independently from one another

Isabelle Boutin-Ganache1, Sylvie Picard1, and Christian F Deschepper1*

1 Experimental Cardiovascular Biology, IRCM, Montreal, QC, Canada

* To whom correspondence should be addressed. E-mail: deschec{at}ircm.qc.ca.

WKY and WKHA are 2 genetically-related inbred strains of rats that are both normotensive yet exhibit differences in left ventricular mass (LVM). We had shown previously that cardiomyocytes from male WKHA are wider than that of male WKY, and that there was genetic linkage between LVM and a locus on chromosome 5 (RNO5) in the male progeny of a F2 WKHA/WKY cross. We show here that cardiomyocyte width is linked to the same RNO5 locus in male reciprocal congenic rats derived from WKHA and WKY. Contrary to males, we found no genetic linkage between LVM and the RNO5 locus in female rats. However, ventricular hypertrophy in females might be of a different nature, because cardiomyocytes from female WKHA were shorter than their WKY counterparts (with no difference in width). The RNO5 locus contains that of the Natriuretic Peptide Precursor A (Nppa) gene. In male congenic rats, changes in cardiomyocyte width always correlated with reciprocal changes in the LV concentration of atrial natriuretic factor (ANF, i.e. the peptide product of Nppa). Taken together with other functional data, the small size of the RNO5 locus (~63 cR) increased the likelihood that both cardiomyocyte width and LV ANF concentration could be linked to only one gene (possibly Nppa) in male rats. Moreover, our results support the notion that genes and gender interact to regulate cardiomyocyte width and length independently from one another.




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