Physiol. Genomics AJP: Heart and Circulatory Physiology
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Physiol. Genomics (October 14, 2003). doi:10.1152/physiolgenomics.00106.2003
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Submitted on June 30, 2003
Accepted on October 13, 2003

Genetic interaction between a maternal factor and the zygotic genome controls the intestine length in PRM/Alf mice

Genevieve Aubin-Houzelstein1, Nelly R Da Silva1, Sylvain Bellier2, Pierrick Salaun2, Xavier Montagutelli3, and Jean-Jacques Panthier1*

1 Ecole Nationale Veterinaire d'Alfort, UMR955 INRA-ENVA de Genetique Moleculaire et Cellulaire, Maisons-Alfort, France; Unite de Genetique des Mammiferes, Institut Pasteur, Paris Cedex, France
2 Ecole Nationale Veterinaire d'Alfort, UMR955 INRA-ENVA de Genetique Moleculaire et Cellulaire, Maisons-Alfort, France
3 Unite de Genetique des Mammiferes, Institut Pasteur, Paris Cedex, France

* To whom correspondence should be addressed. E-mail: jjpanthier{at}vet-alfort.fr.

Postoperative management of small and large bowel resections would be helped by use of intestinotrophic molecules. Here, we present a mouse inbred strain called PRM/Alf that is characterized by a selective intestinal lengthening. We show that PRM/Alf intestine is one third longer compared to other inbred strains. The phenotype is acquired mostly during the postnatal period, before weaning. Its genetic determinism is polygenic, and involves a strong maternal effect. Cross-fostering experiments revealed that the dam's genotype acts synergistically with the offspring's genotype to confer the longest intestine. Moreover, genes in the offspring have a direct effect on intestine length. Possible involvement of milk growth factors and identification of candidate genes are discussed.




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