Physiol. Genomics Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Physiol. Genomics (February 19, 2002). doi:10.1152/physiolgenomics.00105.2001
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
9/1/1    most recent
00105.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Streelman, J. T
Right arrow Articles by Kocher, T. D
Right arrow Search for Related Content
PubMed
Right arrow Articles by Streelman, J. T
Right arrow Articles by Kocher, T. D

Articles in PresS, published online ahead of print February 19, 2002
Physiol Genomics, 10.1152/physiolgenomics.00105.2001
Submitted on November 6, 2001
Accepted on February 11, 2002

Microsatellite Length Variation is Associated With Prolactin Expression and Growth Response of Salt-challenged Tilapia

Jeffrey T Streelman1* and Thomas D Kocher1

1 Program in Genetics, Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH, USA

* To whom correspondence should be addressed. E-mail: jts3{at}hopper.unh.edu.

Biologists have long argued that runs of alternating purines and pyrimidines could form alternative DNA structures, which might regulate transcription. Here, we report that simple sequence repeat polymorphisms in the tilapia prolactin 1 ( prl 1)promoter are associated with differences in prl 1 gene expression and the growth response of salt-challenged fishes. Individuals homozygous for long microsatellite alleles express less prl 1 in fresh water but more prl 1 in half-seawater than fishes with other genotypes. Our work provides the first in vivo evidence that differences in microsatellite length among individuals may indeed affect gene expression, and that variance in expression has concomitant physiological consequences. These results suggest that dinucleotide microsatellites represent an under-appreciated source of genetic variation for regulatory evolution.




This article has been cited by other articles:


Home page
 Physiol. GenomicsHome page
J. Estany, M. Tor, D. Villalba, L. Bosch, D. Gallardo, N. Jimenez, L. Altet, J. L. Noguera, J. Reixach, M. Amills, et al.
Association of CA repeat polymorphism at intron 1 of insulin-like growth factor (IGF-I) gene with circulating IGF-I concentration, growth, and fatness in swine
Physiol Genomics, October 19, 2007; 31(2): 236 - 243.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
V. K. Sharma, N. Kumar, S. K. Brahmachari, and S. Ramachandran
Abundance of dinucleotide repeats and gene expression are inversely correlated: a role for gene function in addition to intron length
Physiol Genomics, September 11, 2007; 31(1): 96 - 103.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
D. Wang, H.-M. Sung, T.-Y. Wang, C.-J. Huang, P. Yang, T. Chang, Y.-C. Wang, D.-L. Tseng, J.-P. Wu, T.-C. Lee, et al.
Expression evolution in yeast genes of single-input modules is mainly due to changes in trans-acting factors
Genome Res., August 1, 2007; 17(8): 1161 - 1169.
[Abstract] [Full Text] [PDF]

Home page
 J MOLLUS STUDHome page
A. Zhan, J. Hu, X. Wang, W. Lu, M. Hui, and Z. Bao
A panel of polymorphic EST-derived microsatellite loci for the bay scallop (Argopecten irradians)
J. Mollus. Stud., November 1, 2006; 72(4): 435 - 438.
[Full Text]

Home page
 Mol Biol EvolHome page
Y.-C. Li, A. B. Korol, T. Fahima, and E. Nevo
Microsatellites Within Genes: Structure, Function, and Evolution
Mol. Biol. Evol., June 1, 2004; 21(6): 991 - 1007.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
G. A. Wray, M. W. Hahn, E. Abouheif, J. P. Balhoff, M. Pizer, M. V. Rockman, and L. A. Romano
The Evolution of Transcriptional Regulation in Eukaryotes
Mol. Biol. Evol., September 1, 2003; 20(9): 1377 - 1419.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2002 by the American Physiological Society.