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Physiol. Genomics (December 4, 2001). doi:10.1152/physiolgenomics.00080.2001
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Articles in PresS, published online ahead of print December 3, 2001
Physiol Genomics, 10.1152/physiolgenomics.00080.2001
Submitted on September 10, 2001
Accepted on November 27, 2001

Two Closely Linked Interactive Blood Pressure QTL on Rat Chromosome 5 Defined Using Congenic Dahl Rats

Michael R Garrett1 and John P Rapp1*

1 Physiology & Molecular Medicine, Medical College of Ohio, Toledo, Ohio, USA

* To whom correspondence should be addressed. E-mail: jrapp{at}mco.edu.

Previously we reported the construction of a congenic strain, S.LEW(5), spanning a large region of rat chromosome 5. The Lewis (LEW) strain was the donor and the Dahl salt-sensitive (S) strain was the recipient. The congenic strain included a blood pressure quantitative trait locus (QTL). In the present work, a series of nine congenic substrains were constructed from S.LEW(5) which defined two closely linked blood pressure QTL in the region previously thought to contain only one. LEW low-blood-pressure alleles at both QTL were required for a major effect on blood pressure. Neither LEW allele alone had a significant effect on blood pressure. The two QTL were localized to regions 6.3 and 4.6 cM and these were 1.0 cM apart.




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