Physiol. Genomics Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Physiol. Genomics (June 29, 2004). doi:10.1152/physiolgenomics.00079.2004
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
19/1/50    most recent
00079.2004v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wansink, D. G
Right arrow Articles by Hendriks, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wansink, D. G
Right arrow Articles by Hendriks, W.
Submitted on April 1, 2004
Accepted on June 24, 2004

Mild Impairment of Motor Nerve Repair in Mice Lacking PTP-BL Tyrosine Phosphatase Activity

Derick G Wansink1, Wilma Peters1, Iris Schaafsma1, Roger P. M Sutmuller2, Frank Oerlemans1, Gosse J Adema2, Be Wieringa1, Catharina E. E. M van der Zee1, and Wiljan Hendriks1*

1 Department of Cell Biology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, Nijmegen, The Netherlands
2 Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, Nijmegen, The Netherlands

* To whom correspondence should be addressed. E-mail: w.hendriks{at}ncmls.kun.nl.

Mouse PTP-BL is a large, non-transmembrane protein tyrosine phosphatase of unclear physiological function that consists of a KIND domain, a FERM domain, five PDZ domains and a C-terminal catalytic PTP domain. PTP-BL and its human ortholog PTP-BAS have been proposed to play a role in the regulation of microfilament dynamics, cytokinesis, apoptosis and neurite outgrowth. To investigate the biological function of PTP-BL enzyme activity, we have generated mice that lack the PTP-BL PTP moiety. These PTP-BL{Delta}P/{Delta}P mice are viable and fertile and do not present overt morphological alterations. Although PTP-BL is expressed in most hematopoietic cell lineages, no alterations of thymocyte development in PTP-BL{Delta}P/{Delta}P mice could be detected. Sciatic nerve lesioning revealed that sensory nerve recovery is unaltered in these mice. In contrast, a very mild but significant impairment of motor nerve repair was observed. Our findings exclude an essential role for PTP-BL as a phosphotyrosine phosphatase and rather are in line with a role as scaffolding or anchoring molecule.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
C. E. E. M. Van der Zee, M. Kreft, G. Beckers, A. Kuipers, and A. Sonnenberg
Conditional Deletion of the Itgb4 Integrin Gene in Schwann Cells Leads to Delayed Peripheral Nerve Regeneration
J. Neurosci., October 29, 2008; 28(44): 11292 - 11303.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
H. J Welters, A. Oknianska, K. S Erdmann, G. U Ryffel, and N. G Morgan
The protein tyrosine phosphatase-BL, modulates pancreatic {beta}-cell proliferation by interaction with the Wnt signalling pathway
J. Endocrinol., June 1, 2008; 197(3): 543 - 552.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
W. C. Spanos, A. Hoover, G. F. Harris, S. Wu, G. L. Strand, M. E. Anderson, A. J. Klingelhutz, W. Hendriks, A. D. Bossler, and J. H. Lee
The PDZ Binding Motif of Human Papillomavirus Type 16 E6 Induces PTPN13 Loss, Which Allows Anchorage-Independent Growth and Synergizes with Ras for Invasive Growth
J. Virol., March 1, 2008; 82(5): 2493 - 2500.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Dromard, G. Bompard, M. Glondu-Lassis, C. Puech, D. Chalbos, and G. Freiss
The Putative Tumor Suppressor Gene PTPN13/PTPL1 Induces Apoptosis through Insulin Receptor Substrate-1 Dephosphorylation
Cancer Res., July 15, 2007; 67(14): 6806 - 6813.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2004 by the American Physiological Society.