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Physiol. Genomics (September 17, 2002). doi:10.1152/physiolgenomics.00078.2002
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Articles in PresS, published online ahead of print September 17, 2002
Physiol Genomics, 10.1152/physiolgenomics.00078.2002
Submitted on June 24, 2002
Accepted on September 12, 2002

Differentially Abundant mRNAs in Rat Liver in Response to Diets Containing Soy Protein Isolate

Muhammad J Iqbal1*, Satsuki Yaegashi2, Rubina Ahsan2, David A Lightfoot2, and William J Banz3

1 Animal Science, Food and Nutrition, Southern Illinois University, Carbondale, IL, USA; Department of Plant, Soil and General Agriculture, Southern Illinois University, Carbondale, IL, USA
2 Department of Plant, Soil and General Agriculture, Southern Illinois University, Carbondale, IL, USA; Plant, Soil and General Agriculture, Southern Illinois University, Carbondale, IL, USA
3 Animal Science, Food and Nutrition, Southern Illinois University, Carbondale, IL, USA; Animal Science, Food and Nutrition, Southern Illinois University, Carbondale, IL, USA

* To whom correspondence should be addressed. E-mail: mjiqbal{at}siu.edu.

Soy diets influence cell growth, regulate lipid metabolism to lower blood cholesterol and prevent bone losses. These biological effects are most likely due to effects of soy phytochemicals on the expression of genes. In this study, we fed 12 female obese Zucker rats (fa/fa) with a low- or a high-isoflavone soy protein diet and compared the gene expression with animals on a casein diet. Rat livers were compared by differential display of mRNA and 62 unique sequences were identified. The change in mRNA abundance of these sequences was quantified by cDNA macroarray analysis. Thirty three mRNAs showed more than two fold increase in abundance on soy diets compared to the control. The corresponding genes include carnitine palmitoyltransferase I, stromal cell derived factor 1, a protein associated with MYC mRNA, basic transcription element binding protein, and ESTs of unknown function. Twenty nine mRNAs showed a less than two fold change in abundance in the two diet treatments. For majority of the genes identified, there was not significant difference between the low- and high-isoflavone diet treatments. Therefore, the contrast between soy protein and casein caused the changes observed in mRNA abundance.




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