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Articles in PresS, published online ahead of print November 15, 2001
Physiol Genomics, 10.1152/physiolgenomics.00074.2001
Submitted on September 4, 2001
Accepted on November 7, 2001
1 W.M. Keck Ctr. Collab. Neurosci., Rutgers University, Piscataway, NJ, USA
2 Ctr. Collab. Genomics, Public Health Research Institute, Newark, NJ, USA
3 UMDNJ, New Jersey Medical School, Newark, NJ, USA
4 W.M. Keck Ctr. Collab. Neurosci., Rutgers University, Piscataway, NJ, USA; Dept. Biol. Sci., Rutgers University, Newark, NJ, USA; Ctr. for Comp. Biol. & Bioeng., New Jersey Institute of Technology, Newark, NJ, USA
* To whom correspondence should be addressed. E-mail: rhart{at}andromeda.rutgers.edu.
We have completed the first large-scale gene expression study of acute spinal cord injury in rat. Oligonucleotide microarrays containing 1,200 gene-specific probes were used to quantify mRNA levels, relative to uninjured controls, in spinal cords injured using a standard contusion model. Our results revealed a marked loss of neuron-specific mRNAs at the injury site. The surviving cells showed a characteristic inflammatory response that started at the injury site and spread to the distal cord. Changes in several mRNA levels were associated with putative regenerative responses in the spinal cord. Notably, phosphodiesterase 4, nestin, glial-derived neurite promoting factor, and GAP-43 mRNAs increased significantly. Other mRNAs clustered temporally and spatially with these regeneration-associated genes. Thus, we have described global patterns of gene expression following acute spinal cord injury, and we have identified targets for future study and possible therapeutic intervention.
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