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Physiol. Genomics (May 24, 2005). doi:10.1152/physiolgenomics.00073.2005
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Submitted on March 29, 2005
Accepted on May 20, 2005

Gene expression profile and aortic vessel distensibility in voluntarily exercised spontaneously hypertensive rats - potential role of heat shock proteins

Ulrika Hagg1, Maria E Johansson1, Julia Gronros1, Andrew S Naylor1, Ingibjorg H Jonsdottir2, Goran Bergstrom3, Per-Arne Svensson4, and Li-ming Gan3*

1 Dept. of Physiology, Inst. of Physiology & Pharmacology, Gothenburg, Sweden
2 Dept. of Physiology, Inst. of Physiology & Pharmacology, Gothenburg, Sweden; Inst. of Stress Medicine, Gothenburg, Sweden
3 Dept. of Physiology, Inst. of Physiology & Pharmacology, Gothenburg, Sweden; Dept. of Clinical Physiology, Cardiovascular Institute, Gothenburg, Sweden
4 Dept. of Internal Medicine, Research Centre for Endocrinology and Metabolism (RCEM), Gothenburg, Sweden

* To whom correspondence should be addressed. E-mail: li-ming.gan{at}hjl.gu.se.

Physical exercise is considered to be beneficial for the cardiovascular health. Nevertheless, the underlying specific molecular mechanisms still remain unexplored. In this study we aimed to investigate the effects of voluntary exercise on vascular mechanical properties and gene regulation patterns in spontaneously hypertensive rats. By using ultrasound biomicroscopy (UBM) in an ex vivo perfusion chamber we studied the distensibility of the thoracic aorta. Further, exercise-induced gene regulation was studied in aortae, using microarray analysis, and validated with real-time PCR. We found that distensibility was significantly improved in aortas from exercising compared to control rats (p<0.0001). Exercising rats demonstrated a striking pattern of coordinated down-regulation of genes belonging to the heat shock protein (HSP) family. In conclusion, voluntary exercise leads to improved vessel wall distensibility and reduced gene expression of HSP60 and HSP70, which may indicate decreased oxidative stress in the aortic vascular wall.




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