Physiol. Genomics Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Physiol. Genomics (July 23, 2002). doi:10.1152/physiolgenomics.00065.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
10/3/199    most recent
00065.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Alemayehu, A.
Right arrow Articles by Printz, M. P
Right arrow Search for Related Content
PubMed
Right arrow Articles by Alemayehu, A.
Right arrow Articles by Printz, M. P

Articles in PresS, published online ahead of print July 23, 2002
Physiol Genomics, 10.1152/physiolgenomics.00065.2002
Submitted on May 28, 2002
Accepted on July 18, 2002

Reciprocal Rat Chromosome 2 Congenic Strains Reveal Contrasting Blood Pressure and Heart Rate Quantitative Trait Loci

Adamu Alemayehu1*, Laura Breen1, Drahomira Krenova1, and Morton P Printz1

1 Department of Pharmacology, University of California San Diego, La Jolla, California, USA

* To whom correspondence should be addressed. E-mail: aalemayehu{at}ucsd.edu.

Evidence exists implying multiple blood pressure quantitative trait loci (QTL) on rat chromosome 2. To examine this possibility, four congenic strains and nine substrains were developed with varying-sized chromosome segments introgressed from the spontaneously hypertensive (SHR/lj) and normotensive Wistar-Kyoto (WKY/lj) rat onto the reciprocal genetic background. Cardiovascular phenotyping was conducted with telemetry over extended periods during standard (0.7%) and high (8%) salt diets. Our results are consistent with at least three independent pressor QTL: transfer of SHR/lj alleles to WKY/lj reveals pressor QTL within D2Rat21-D2Rat27 and D2Mgh10-D2Rat62, while transfer of WKY/lj D2Rat161-D2Mit8 to SHR/lj reveals a depressor locus. Our results also suggest a depressor QTL in SHR/lj located within D2Rat161-D2Mgh10. Introgressed WKY/lj segments also reveal a heart rate QTL within D2Rat40-D2Rat50 which abolished salt-induced bradycardia, dependent upon adjoining SHR/lj alleles. This study confirms the presence of multiple blood pressure QTLs on chromosome 2. Taken together with our other studies, we conclude that rat chromosome 2 is rich in alleles for cardiovascular and behavioral traits and for coordinated coupling between behavior and cardiovascular responses.




This article has been cited by other articles:


Home page
 Hum Mol GenetHome page
A. Y. Deng
Genetic basis of polygenic hypertension
Hum. Mol. Genet., October 15, 2007; 16(R2): R195 - R202.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
S. Charron, R. Lambert, V. Eliopoulos, C. Duong, A. Menard, J. Roy, and A. Y. Deng
A loss of genome buffering capacity of Dahl salt-sensitive model to modulate blood pressure as a cause of hypertension
Hum. Mol. Genet., December 15, 2005; 14(24): 3877 - 3884.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
V. Eliopoulos, J. Dutil, Y. Deng, M. Grondin, and A. Y. Deng
Severe hypertension caused by alleles from normotensive Lewis for a quantitative trait locus on chromosome 2
Physiol Genomics, June 16, 2005; 22(1): 70 - 75.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
J. Dutil, V. Eliopoulos, E.-L. Marchand, A. M. Devlin, J. Tremblay, K. Prithiviraj, P. Hamet, A. Migneault, D. deBlois, and A. Y. Deng
A quantitative trait locus for aortic smooth muscle cell number acting independently of blood pressure: implicating the angiotensin receptor AT1B gene as a candidate
Physiol Genomics, May 11, 2005; 21(3): 362 - 369.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
J. Dutil, V. Eliopoulos, J. Tremblay, P. Hamet, S. Charron, and A. Y. Deng
Multiple Quantitative Trait Loci for Blood Pressure Interacting Epistatically and Additively on Dahl Rat Chromosome 2
Hypertension, April 1, 2005; 45(4): 557 - 564.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
M. Grondin, V. Eliopoulos, R. Lambert, Y. Deng, A. Ariyarajah, M. Moujahidine, J. Dutil, S. Charron, and A. Y. Deng
Complete and overlapping congenics proving the existence of a quantitative trait locus for blood pressure on Dahl rat chromosome 17
Physiol Genomics, March 21, 2005; 21(1): 112 - 116.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
L. J. Martin, A. G. Comuzzie, G. E. Sonnenberg, J. Myklebust, R. James, J. Marks, J. Blangero, and A. H. Kissebah
Major Quantitative Trait Locus for Resting Heart Rate Maps to a Region on Chromosome 4
Hypertension, May 1, 2004; 43(5): 1146 - 1151.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
C. A. Mein, M. J. Caulfield, R. J. Dobson, and P. B. Munroe
Genetics of essential hypertension
Hum. Mol. Genet., April 1, 2004; 13(90001): R169 - 175.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. P. Printz, M. Jirout, R. Jaworski, A. Alemayehu, and V. Kren
Genetic Models in Applied Physiology: Invited Review: HXB/BXH rat recombinant inbred strain platform: a newly enhanced tool for cardiovascular, behavioral, and developmental genetics and genomics
J Appl Physiol, June 1, 2003; 94(6): 2510 - 2522.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2002 by the American Physiological Society.