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Physiol. Genomics (September 21, 2001). doi:10.1152/physiolgenomics.00061.2001
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Articles in PresS, published online ahead of print September 21, 2001
Physiol Genomics, 10.1152/physiolgenomics.00061.2001
Submitted on July 25, 2001
Accepted on September 6, 2001

Reprogramming the expression of categorically related genes during human uterine fibroblast decidualization

Anoop K Brar1*, Stuart Handwerger1, Cherie A Kessler1, and Bruce J Aronow2

1 Endocrinology, Children's Hospital Medical Center, Cincinnati, Ohio, USA
2 Molecular and Developmental Biology and Bioinformatics, Children's Hospital Medical Center, Cincinnati, Ohio, USA

* To whom correspondence should be addressed. E-mail: stuart.handwerger{at}chmcc.org.

Human decidual fibroblast differentiation is an excellent in vitro model of uterine decidualization, a process critical for embryo implantation and placental function. We characterized gene expression pattern kinetics during decidual fibroblast differentiation by microarray analysis. Of 6918 genes analyzed, 121 genes were induced by more than 2-fold, 110 were down-regulated, and 50 showed biphasic behavior. Dynamically regulated genes were could be fit into nine K-means algorithm-based kinetic pattern groups, and by biologic classification, into five categories: cell and tissue function, cell and tissue structure, regulation of gene expression, EST, and function-unknown. Reprogramming of genes within specific functional groups and gene families was a prominent feature that consisted of simultaneous induction and down regulation of a set of genes with related function. We previously observed a conceptually similar process during fetal trophoblast differentiation, in which the same phenomena applied to different genes. Of the 569 dynamically regulated genes regulated by either model, only 81 of these were in common. These results suggest that reprogramming of gene expression within focused functional categories represents a fundamental aspect of cellular differentiation.




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