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Articles in PresS, published online ahead of print June 11, 2002
Physiol Genomics, 10.1152/physiolgenomics.00050.2002
Submitted on April 29, 2002
Accepted on June 10, 2002
1 Department of Physiology, Kuopio Research Institute of Exercise Medicine, University of Kuopio, Kuopio, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
2 Department of Physiology, Kuopio Research Institute of Exercise Medicine, University of Kuopio, Kuopio, Finland; Department of Physiology, University of Kuopio, Kuopio, Finland
3 Department of Physiology, Kuopio Research Institute of Exercise Medicine, University of Kuopio, Kuopio, Finland; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA
4 Department of Physiology, Kuopio Research Institute of Exercise Medicine, University of Kuopio, Kuopio, Finland; Department of Clinical Chemistry, Kuopio University Hospital, Kuopio, Finland; Department of Clinical Chemistry, Kuopio University Hospital, Kuopio, Finland
5 Computing Centre, University of Kuopio, Kuopio, Finland
6 Peurunka Rehabilitation Centre, Laukaa, Finland
7 Department of Physiology, Kuopio Research Institute of Exercise Medicine, University of Kuopio, Kuopio, Finland; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA
8 Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA
* To whom correspondence should be addressed. E-mail: rainer.rauramaa{at}uku.fi.
We investigated the role of the angiotensinogen (AGT) gene M235T polymorphism in determining blood pressure (BP) response to moderate intensity exercise in a 6-year randomized controlled trial in 140 middle-aged men. Sitting, supine and standing blood pressure was measured annually. Of the randomized men, 86 % participated in the trial for six years. Submaximal cardiorespiratory fitness increased by 16 % in the exercise group. In the M homozygotes, sitting systolic BP decreased by 1.0 mmHg in the exercise, but increased by 14.6 mmHg in the reference group (p=0.007 for net effect). Sitting and supine diastolic BP decreased by 6.2 and 3.3 mmHg in the exercise, but increased by 2.8 and 3.2 mmHg in the reference group (p=0.026 and 0.024 for net effects), respectively. Regular moderate intensity exercise attenuates aging related increase in systolic BP and decreases diastolic BP among the M homozygotes of the AGT gene M235T polymorphism.
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