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Articles in PresS, published online ahead of print September 11, 2002
Physiol Genomics, 10.1152/physiolgenomics.00048.2002
Submitted on April 23, 2002
Accepted on September 4, 2002
1 School of Kinesiology, University of Minnesota, Minneapolis, MN, USA; Research Service, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN, USA
2 Research Service, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN, USA
3 Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan, Ann Arbor, MI, USA
4 Research Service, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
* To whom correspondence should be addressed. E-mail: denge001{at}umn.edu.
We evaluated the association between insulin resistance and the angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) gene polymorphism in a group of older hypertensive subjects (63±1 yrs, n=35) before and after a 6-mo aerobic exercise program (AEX). Insulin sensitivity index (SI), assessed by the frequently sampled intravenous glucose tolerance test was significantly (P=0.0001) increased following AEX. In addition, there was a significant (P=0.001) interaction between AEX and ACE genotype. SI increased significantly (P<0.05) more in those with the II (2.5±0.8 x 10-4/min/µU/mL) ACE genotype compared with both the DD and ID (0.7±0.1 and 0.7±0.2 x10-4/min/µU/mL, respectively) ACE genotypes. Similarly there was a significant (P=0.036) decrease in the acute insulin response to glucose (AIRG) and a significant (P=0.05) interaction between AEX and ACE genotype. AIRG decreased significantly (P<0.05) more in those with the II (-17.6±5.6 mU/ml) ACE genotype compared with both the DD and ID (-1.4±6.2 and -3.6±2.5 mU/ml)ACE genotypes. In conclusion, we demonstrated that those older hypertensives with the ACE II genotype have the greatest improvement in insulin action following AEX.
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