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Articles in PresS, published online ahead of print August 8, 2001
Physiol Genomics, 10.1152/physiolgenomics.00048.2001
Submitted on June 6, 2001
Accepted on July 13, 2001
1 Biochemistry and Physiology of Nutrition, German Institute of Human Nutrition, Bergholz-Rehbrucke, Germany
2 Department of Biology, Philipps-University, Marburg, Germany
3 Department of Safety and Health of Food, RIKILT, Wageningen, Netherlands
* To whom correspondence should be addressed. E-mail: klaus{at}www.dife.de.
White (WAT) and brown (BAT) adipose tissue are tissues of energy storage and energy dissipation, respectively. Experimental evidence suggests that brown and white preadipocytes are differentially determined, but so far not much is known about the genetic control of this determination process. The aim of this study was to identify differentially expressed genes involved in brown and white preadipocyte development. Using representational difference analysis (cDNA RDA) and DNA microarray screening, four genes were identified with higher expression in white preadipocytes (three different complement factors and delta 6 fatty acid desaturase) and seven genes with higher expression levels in brown preadipocytes of which three are structural genes implicated in cell adhesion and cytoskeleton organization (fibronectin, alpha-actinin 4, metargidin), and four which might function in gene transcription and protein synthesis (vigilin, necdin, snRNP polypeptide A, and a homologue to human hepatocellular carcinoma associated protein). The expression profile of these genes was analysed during preadipocyte differentiation, upon beta-adrenergic stimulation and in WAT and BAT tissue in vivo in comparison to references genes such as PPAR
, UCP1, cytochrome c oxidase.
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