Physiol. Genomics AJP: Cell Physiology
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Physiol. Genomics (October 16, 2001). doi:10.1152/physiolgenomics.00041.2001
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Articles in PresS, published online ahead of print October 16, 2001
Physiol Genomics, 10.1152/physiolgenomics.00041.2001
Submitted on June 1, 2001
Accepted on October 2, 2001

Influence of Ethanol on Thermoregulation - Mapping Quantitative Trait Loci

Larry I Crawshaw1*, Helen Wallace2, Robin Christensen2, and John C Crabbe3

1 Biology, Portland State University, Portland, Oregon, USA; Behavioral Neuroscience/ Portland Alcohol Research Center, Oregon Health & Science University, Portland, Oregon, USA
2 Biology, Portland State University, Portland, Oregon, USA
3 Behavioral Neuroscience/ Portland Alcohol Research Center, Oregon Health & Science University, Portland, Oregon, USA

* To whom correspondence should be addressed. E-mail: crawshl{at}psu4.pdx.edu.

The genetic basis for the effects of ethanol on thermoregulation was investigated by utilizing recombinant inbred mouse strains from C57BL/6J and DBA/2J progenitor strains. Changes in core body temperature (Tc) and the degree of fluctuation of Tc were monitored in male mice following the administration of ethanol in an environment with cyclic changes in ambient temperature (Ta). Changes in Tc were utilized to assess ethanol induced effects on regulated Tc while fluctuations in Tc were utilized to assess thermoregulatory disruption. Ethanol was administered at 1.5, 2.5, and 3.5 g/kg (i.p.) for all strains. Change in Tc and increase in tail temperature were also evaluated at 2.5 g/kg ethanol in a constant Ta of 26 °C. Associations between the measured physiological responses and previously mapped genetic markers were used to identify Quantitative Trait Loci (QTLs). This established probable chromosome locations for a number of genes for the responses. To our knowledge, this is the first report of QTLs that underlie changes in regulation as well as the disruption of a physiological regulatory system.




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