| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Medicine, Research Centre-CHUM, Montreal, Quebec, Canada
2 Internal medicine, Third People's Hospital of Yunnan, Kunming, Yunnan, China
* To whom correspondence should be addressed. E-mail: alan.deng{at}umontreal.ca.
Pursuing fully a suggestion from linkage analysis that there might be a quantitative trait locus (QTL) for blood pressure (BP) in a Chromosome (Chr) 2 region of the Dahl salt-sensitive rat (DSS), four congenic strains were made by replacing various fragments of DSS Chr 2 with those of Lewis (LEW). Consequently, a BP QTL was localized to a segment of around 3 centiMorgan (cM) or near 3 megabases (Mbs) on Chr 2 by comparative congenics. The BPaugmenting alleles of this QTL originated from the LEW rat, a normotensive strain compared to DSS. The dissection of a QTL with such a paradoxical effect illustrated the power of congenics in unearthing a gene hidden in the context of the whole animal system presumably by interactions with other genes. The locus for the angiotensin II receptor AT1B (Agtr1b) is not supported as a candidate gene for the QTL because a congenic strain harboring it did not have an effect on BP. There are approximately 19 known and unknown genes present in the QTLinterval. Among them, no standout candidate genes are reputed to affect BP. Thus the QTL will likely represent a novel gene for BP regulation.
This article has been cited by other articles:
|
|
 |
|
  A. Y. Deng Genetic basis of polygenic hypertension Hum. Mol. Genet., October 15, 2007; 16(R2): R195 - R202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Y. Deng Positional Cloning of Quantitative Trait Loci for Blood Pressure: How Close Are We?: A Critical Perspective Hypertension, April 1, 2007; 49(4): 740 - 747. [Full Text] [PDF]
|
|
|
|
|
|
P. B. Munroe, C. Wallace, M.-Z. Xue, A. C. B. Marcano, R. J. Dobson, A. K. Onipinla, B. Burke, J. Gungadoo, S. J. Newhouse, J. Pembroke, et al. Increased Support for Linkage of a Novel Locus on Chromosome 5q13 for Essential Hypertension in the British Genetics of Hypertension Study Hypertension, July 1, 2006; 48(1): 105 - 111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Charron, R. Lambert, V. Eliopoulos, C. Duong, A. Menard, J. Roy, and A. Y. Deng A loss of genome buffering capacity of Dahl salt-sensitive model to modulate blood pressure as a cause of hypertension Hum. Mol. Genet., December 15, 2005; 14(24): 3877 - 3884. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Liang and B. Ventura Physiological genomics in PG and beyond: October to December 2005 Physiol Genomics, December 14, 2005; 24(1): 1 - 3. [Full Text] [PDF]
|
|
|
|
|
|
S. Charron, C. Duong, A. Menard, J. Roy, V. Eliopoulos, R. Lambert, and A. Y. Deng Epistasis, Not Numbers, Regulates Functions of Clustered Dahl Rat Quantitative Trait Loci Applicable to Human Hypertension Hypertension, December 1, 2005; 46(6): 1300 - 1308. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
