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Articles in PresS, published online ahead of print June 25, 2002
Physiol Genomics, 10.1152/physiolgenomics.00011.2002
Submitted on February 5, 2002
Accepted on June 19, 2002
1 Genomics, Wyeth/Genetics Institute, Cambridge, MA, USA
* To whom correspondence should be addressed. E-mail: cmiller{at}wyeth.com.
Studies described here utilize high-density oligonucleotide arrays to characterize changes in global mRNA expression patterns during proliferation, cell cycle withdrawal and terminal differentiation in mouse C2C12 myoblasts. Statistical analyses revealed 629 sequences differentially regulated between proliferating and differentiating myoblasts. These genes were clustered using self-organizing maps to identify sets of co-regulated genes and were assigned to functional categories that were analyzed for distribution across expression clusters. Clusters were identified with statistically significant enrichment of functional categories including muscle contraction, cell adhesion, extracellular matrix function, cellular metabolism, mitochondrial transport, DNA replication, cell cycle control, mRNA transcription, and unexpectedly, immune regulation. In addition, functional category enrichment data can be used to predict gene function for numerous differentially regulated ESTs. The results provide new insight into how genes involved in these cellular processes may play a role in skeletal muscle growth and differentiation.
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