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Physiol. Genomics (March 28, 2006). doi:10.1152/physiolgenomics.00009.2006 Free Article
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Submitted on January 20, 2006
Accepted on March 3, 2006

Purine and folate metabolism as potential target of sex specific nutrient allocation in Drosophila and its implication for lifespan-reproduction trade-off

Matthias Bauer1, Jorg D. Katzenberger2, Anne C Hamm1, Melanie Bonaus1, Ingo Zinke1, Jens Jaekel3, and Michael J Pankratz1*

1 Institut fuer Genetik, Forschungszentrum Karlsruhe, Karlsruhe, Germany
2 HAMILTON Life Science Robotics, Fraunhoferstr. 17, Martinsried, 82061, Germany; HAMILTON Life Science Robotics, Martinsried, Germany
3 Institut fuer Angewandte Informatik, Forschungszentrum Karlsruhe, Karlsruhe, Germany

* To whom correspondence should be addressed. E-mail: michael.pankratz{at}itg.fzk.de.

Re-allocation of metabolic resources is important for survival during periods of limited nutrient intake. This has influence on diverse physiological processes, including reproduction, repair and aging. One important aspect of resource allocation is the difference between males and females in response to nutrient stress. We have identified several groups of genes that are regulated in a sex biased manner under complete or protein starvation. These range from expected differences in genes involved in reproductive physiology, to those involved in amino acid utilization, sensory perception, immune response and growth control. A striking difference was observed in purine and the tightly interconnected folate metabolism upon protein starvation. From these results, we conclude that the purine and folate metabolic pathway is a major point of transcriptional regulation during resource allocation, and may have relevance for understanding the physiological basis for the observed trade-off between reproduction and longevity.




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