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Physiol. Genomics (February 25, 2002). doi:10.1152/physiolgenomics.00006.2002
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Articles in PresS, published online ahead of print February 25, 2002
Physiol Genomics, 10.1152/physiolgenomics.00006.2002
Submitted on January 22, 2002
Accepted on February 22, 2002

The Hypertrophic Heart Rat - a new normotensive model of experimental genetic cardiac and cardiomyocyte hypertrophy

Stephen B Harrap1*, Vennetia R Danes1, Justine A Ellis1, Cory D Griffiths1, Elizabeth F Jones1, and Leanne M Delbridge1

1 Physiology, University of Melbourne, Victoria, Australia

* To whom correspondence should be addressed. E-mail: s.harrap{at}unimelb.edu.au.

We describe a new line of rats with inherited cardiomyocyte and ventricular hypertrophy. From a second generation cross of spontaneously hypertensive and Fisher 344 rats, we selected for low blood pressure and either high or low echocardiographic left ventricular (LV) mass over 4 generations to establish the Hypertrophic Heart Rat (HHR) and Normal Heart Rat (NHR) lines respectively. After 13 generations of inbreeding, HHR had significantly greater (P < 0.0001) LV mass to body weight ratio (2.68 g/kg, SE: 0.14) than NHR matched for age (1.94 g/kg, SE: 0.02) or body weight (2.13 g/kg, SE: 0.03). The isolated cardiomyocytes of HHR were significantly (P < 0.0001) longer and wider (161 µm, SE: 0.83; 35.6 µm, SE: 2.9) than NHR (132 µm, SE: 1.2; 29.5 µm SE: 0.35). Telemetric 24-hour recordings of mean arterial pressure revealed no significant differences between HHR and NHR. The HHR offers a new model of primary cardiomyocyte hypertrophy with normal blood pressure in which to examine genotypic causes and pathogenetic mechanisms of hypertrophy and its complications.




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