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Articles in PresS, published online ahead of print April 30, 2002
Physiol Genomics, 10.1152/physiolgenomics.00002.2002
Submitted on January 7, 2002
Accepted on April 29, 2002
1 The Jackson Laboratory, Bar Harbor, ME, USA; Laboratory Animal Resource Resource, University Tsukuba, Tsukuba, Ibaraki, Japan
2 The Jackson Laboratory, Bar Harbor, ME, USA
3 The Jackson Laboratory, Bar Harbor, ME, USA; Howard Hughes Medical Institute, Bar Harbor, ME, USA
4 Laboratory Animal Resource Resource, University Tsukuba, Tsukuba, Ibaraki, Japan
* To whom correspondence should be addressed. E-mail: bjp{at}jax.org.
To better understand the genetic basis of essential hypertension, we conducted a quantitative trait locus (QTL) analysis of a population of 207 (BALB/cJ x CBA/CaJ) F2 male mice to identify genomic regions that regulate blood pressure, heart rate, and heart weight. We identified two loci, Bpq6 (blood pressure quantitative locus 6) on Chr 15 (peak, 16 cM; 95% confidence interval,0-25 cM) and Bpq7 on Chr 7 (peak, 42 cM; 95% confidence interval, 35-50 cM) that were significantly associated with blood pressure. We also identified two loci, Hrq1(heart rate quantitative locus 1) and Hrq2, on D2Mit304 (peak, 72 cM; 95% confidence interval 60-80 cM) and D15Mit184 (peak, 25 cM; 95% confidence interval 20-35 cM) respectively that were significantly associated with heart rate. A significant gene-gene interaction for heart rate was found between Hrq1 and D1Mit10 (peak, 57 cM; 95% confidence interval 45-75); the latter QTL was named Hrq3. We identified a significant locus for heart weight, Hwq1 (heart weight quantitative locus 1), at D14Mit67 (peak 38 cM, 95% confidence interval, 20-43 cM). Identification of the genes for these QTL should lead to a better understanding of the causes of essential hypertension.
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