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Physiol. Genomics 9: 137-144, 2002; doi:10.1152/physiolgenomics.00003.2002
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Supplemental Table

Overview of transcriptional upregulation induced by tBHQ in IMR-32 cells

Category of genes Genbank Accession Number SOM clustering (3×4) Description of genes
Cell death/apoptosis D83699 C11 Brain 3UTR of mRNA for neuronal death protein (harakiri)
  N/A C8 Bax delta
Chaperones/ heat shock proteins N/A C0 heat shock protein hsp40 homolog
  X87949 C1 BiP protein (a member of Hsp70 family of chaperones)
  W28493 C2 Heat shock 70kD protein 8 
CNS specific function U79299 C3 neuronal olfactomedin-related ER localized protein
  AF009674 C3 axin (AXIN)
  U40572 C1 beta2-syntrophin (SNT B2)
  M25756 C5 secretogranin II gene
  Z48054 C3 peroxisomal targeting signal 1
  U73304 C4 CB1 cannabinoid receptor (CNR1)
  AB023209 C4 KIAA0992 (palladin)
  N/A C11 Neurofibromatosis 2 Tumor Suppressor
  L27745 C9 Voltage-operated calcium channel, alpha-1 subunit
  AB012851 C8 Musashi (RNA-binding protein)
cytoskeleton AB002323 C7 Dynein, cytoplasmic, heavy polypeptide 1 (KIAA0325) 
  W26631 C4 Microtuble-associated protein 1A 
  X15306 C4 NF-H gene, exon 1
  S67247 C1 smooth muscle myosin heavy chain isoform (Smemb)
  M22299 C4 T-plastin polypeptide
Detoxification and anti-oxidative stress M81600 C7 NAD(P)H-quinone oxidoreductase
  X15722 C6 glutathione reductase
  N/A C3 glutathione transferase M3 (GSTM3)
  Z82244 C2 Heme Oxygenase 1
  N/A C5 breast cancer cytosolic NADP(+)-dependent malic enzyme
  AL049699 C4 malic enzyme 1, soluble (NADP-dependent malic enzyme, malate oxidoreductase)
  D17793 C6 KIAA0119 (aldo-keto reductase family 1)
  U05861 C7 hepatic dihydrodiol dehydrogenase
  X91247 C5 thioredoxin reductase
  L35546 C2 gamma-glutamylcysteine ligase regulatory subunit
  AL031670 C8 Ferritin, light polypeptide-like 1
  J04755 C8 Ferritin H processed pseudogene
  L20941 C7 Ferritin heavy chain
DNA repair N/A C2 Human growth arrest and DNA-damage-inducible protein (gadd45) mRNA
  N/A C4 ERCC5 excision repair protein
Extracellular matrix AL050138 C1 Elastin microfibril interface located protein
  M92642 C8 Alpha-1 type XVI collagen
Glycoprocess U84007 C1 glycogen debranching enzyme isoform 1 (AGL)
  U84011 C5 glycogen debranching enzyme isoform 6 (AGL)
  L12711 C7 Transketolase (tk)
Immunosystem D32129 C7 HLA class-I (HLA-A26) heavy chain 
RNA processing/modification L22009 C11 hnRNP H
  AL03168 C8 Splicing factor, arginine/serine-rich 6 (SRP55-2) (isoform 2)
Signaling L20861 C5 Wnt-5a
  N/A C3 Guanine Nucleotide-Binding Protein Rap2, Ras-Oncogene Related
  AJ011679 C3 Rab6 GTPase activating protein
  D79990 C2 Ras association domain family 2 (KIAA0168)
  L36870 C3 MAP kinase kinase 4 (MKK4)
  U35113 C4 metastasis-associated mta1
  M88714 C8 Bradykinin receptor (BK-2)
  U46751 C0 phosphotyrosine independent ligand p62 for the Lck SH2 domain
  Y13493 C2 protein kinase; Dyrk2
  Z85986 C10 Clone 108K11 on chromosome 6p21 contains SRP20 (protein serine/threnione kinase)
  N/A C11 Interferon-inducible RNA -dependent protein kinase (Pkr) 
  X59656 C11 Crk-like gene CRKL ( protein tyrosine kinase)
  N/A C9 Ptdins 4-kinase (PI4Kb)
  L35594 C4 Autotaxin(ectonucleotide pyrophosphatase/phosphodiesterase)
Transcription regulation D50922 C3 KIAA0132 (kelch-like ECH-associated protein 1)
  U66561 C1 kruppel-related zinc finger protein (ZNF184)
  X78992 C3 ERF-2
  AF078096 C0 forkhead/winged helix-like transcription factor 7 (FKHL7)
  AF040963 C5 Mad4 homolog (Mad4)
  AF096870 C8 Estrogen-responsive B box protein (EBBP)
  X87838 C11 Beta-catenin
  U19969 C3 Two-handed zinc finger protein ZEB
  N/A C9 DNA-binding protein (APRF)
  D88827 C0 Zinc finger protein FPM3
  U10324 C0 NF-90
  X96381 C6 erm
Translation/post-translation regulation U20180 C10 Iron-regulatory protein 2 (IRP2)
  D26600 C8 Proteasome subunit HsN3
Others U29332 C4 heart protein (FHL-2)
  X64728 C1 CHML
  AF055001 C0 Homocysteine-inducible, endoplasmic reticulum stress inducible, ubiquitin-like domain member 1
  AB007865 C3 fibronectin leucine rich transmembrane protein 2 (KIAA0405)
  X54232 C0 heparan sulfate proteaglycan (glypican)
  Z25535 C2 nuclear pore complex protein hnup153
  D19878 C1 transmembrane protein
  U23070 C9 Putative transmembrane protein (nma)
  AL031781 C3 human ortholog of zebrafish Quaking protein homolog ZKQ-1 (isoform 1)
  AF070598 C6 Clone 24410 ABC transporter
  U60644 C7 HU-K4 (phospholipase D)
  AJ131581 C9 Latrophilin-2
  AF061573 C0 protocadherin (PCDH8)
Unknown AL039458 C4 DKFZp434N0910
  AL080143 C3 DKFZp434N043
  AL050261 C0 DKFZp547E2110
  AL096729 C8 DKFZp434D044
  AB007962 C3 KIAA0493
  D38522 C1 KIAA0080
  D26069 C3 KIAA0041
  AB020685 C6 KIAA0878
  D87443 C3 KIAA0254
  AB011169 C3 KIAA0597
  D87437 C6 KIAA0250
  AB018285 C4 KIAA0742
  AB002351 C6 KIAA0353
  AI768188 C1 Homo sapiens cDNA
  AW024285 C3 Homo sapiens cDNA 
  N92920 C3 Homo sapiens cDNA 
  AC004382 C9 CHROMOSOME 16 BAC clone CIT987SK-A-152E5

 





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