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Physiol. Genomics 5: 53-65, 2001;
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Archive Table. Partial list of R-Y repeat elements in various genes and their known or proposed functions 

Gene* Species Repeats Sites Functions GB Acc.#/ Ref.
α1β-adrenergic receptor Rat GAA/GGA 5´flank ?↓ Expression U83985
HLA-F leukocyte antigen Mouse GGA/GAA 5´flank ?Breakpoint X17093
GABAA receptor δ-subunit Rat GAA 5´flank ? X69986
ANF clearance receptor Mouse GAA 5´flank ? D78176
mC26 (GlyCAM-1 protein) Mouse GA/GAA 5´flank ? D16108 
Hoxd-11 Mouse GA 5´flank ? X71422
H2-Mb2 (MHC class II β-subunit) Mouse  GA 5´flank ? U35323
H-2kb Mouse [GAA]3 5´flank ?Silencer X15104
Connexin 43 (heart; smooth muscle) Rat GGA 5´flank ? L36949
Neural cell adhesion (Ncam-c) Rat GGA/GAA  5´flank ↓Expression M32612
TRK oncogene Human GGA 5´UTR ?Breakpoint X03541
hsp47 Zebrafish GAA 5´UTR ? U31079
BS probe-sensitive T. gondii GAA ORF ? U53810
Glutamate-rich protein (GARP) P. falciparum GAA ORF ?Cell immunity J03998
MNN4 Yeast GAA ORF ? D83006
p101 acidic membrane (ABRA)  P. falciparum GAA ORF ?Cell immunity J03902
STRA8 (pre-meiotic germ cell) Mouse GAA ORF ? Z75287
MESA (surface antigen protein) P. falciparum GAA ORF ?Stability M69183
PcEMA1 (acidic phosphoprotein) P. chabaudi GAA ORF ? M95789
Coat proteins (BCMV-B; PRSV-W; SMV[CH, G7]; TamMV) Potyvirus GGA/GAA ORF ?RNA replication slippage/evolution Ref. 1
GABPα ETS domain Mouse [GGA]2 ORF ↑Transcription M74515,6
Caudal homeobox protein (cad) Drosophila GGA ORF ↑Transcription M21069
T cell receptor α-chain  Mouse GGA Joining ?recombination M64239
Frataxin (FRDA) Human GAA Intron 1 ↓Transcription U43748 
H2-Mb1 (MHCclass II β-subunit) Mouse  [GGAGAA]n Intron 3 ?recombination U35323
Cardiac α-myosin heavy chain (MYH6) Human GAA/GGA Intron 15 ? Z20656
Cardiac β-myosin heavy chain (MYH7) Human GA-rich Intron 24 ? X52889
TNF receptor (p75) Human [GGAGAA]n Intron 1 ? U53481
HPRT M. robustus GGA/GAA Intron 3 ? U59897
Polymeric Ig receptor (Pigr) Rat, mouse GGA/GAA 3´UTR ?↓Expression U08273, AB001489
Immunoglobulin IgG2a Mouse GA/GGAA/GGA 3´UTR ?Breakpoint X17562
Retina-specific leu zipper protein  Mouse GGA 3´UTR ? L14935
K+channel rK+K13 Rat GGA/GAA 3´UTR ?Breakpoint M81784
Dendritic 921-L pre-synaptic protein Mouse [GGA, GAA]n 3´UTR ? D38613
Histone (H2A) Sea urchin GGA 3´UTR  ?Enhancer block Y09062
Lens Ω-crystallin  Cephalopod GAA 3´UTR ? L10113
Glial derived neurotrophic factor (GDNF) Human GGA 3´UTR ? AF063586 
pMGA (multi-gene family array) M.gallisepticum GAA Spacer ?Gene switching U90714
Histone (multi-gene family array) Sea urchin GAA Spacer ? V01144
Slp/CYP450 (Cyp21 Mouse GAA/GGA Spacer ? M64933
Unknown (Xq13) Human GGA/GAA bWXD58 ? AC004073 

*The genes listed share significant homology with the Pigr sequence (P(N)<10-60-10-10) determined from NCBI BLAST searches. Negative strand. Ref. 1 is Hancock JM., Chaleeprom W, Chaleeprom W, Dale J, and Gibbs A. Replication slippage in the evolution of potyviruses. J Gen Virol 76: 3229-3232, 1995.





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