Effects of nitroglycerin or pentaerithrityl tetranitrate treatment on the gene expression in rat hearts: evidence for cardiotoxic and cardioprotective effects
Physiol. Genomics Pautz et al.
38: 176
Supplemental Tables
4 tables in PDf format.
Files in this Data Supplement:
Table S1 -
NTG-induced changes in the expression of genes in rat hearts NTG- vs. EtOH-treated or PETN- vs. DMSO-treated ratio values (mean ± SEM) of genes with changes in the expression induced by NTG (only genes with q-values < 5% and ratios NTG vs. EtOH > 2 or < 0.75 are shown; ns: q-value > 5%). Genes are arranged according the Ensembl gene ID. The Ensembl gene IDs, the gene names, the gene descriptions, the EntrezGene IDs, the RefSeq DNA IDs, the Panther molecular function, the q-values, the mean of the ratios of the different experiments (M) and the standard error of the mean (SEM) are shown.
Table S2 -
PETN-induced changes in the expression of genes in rat hearts PETN- vs. DMSO-treated or NTG- vs. EtOH-treated ratio values (mean ± SEM) of genes with changes in the expression induced by PETN (only genes with q-values < 5% and ratios PETN vs. DMSO > 2 or < 0.75 are shown; ns: q-value > 5%). Genes are arranged according the Ensembl gene ID. The Ensembl gene IDs, the gene names, the gene descriptions, the EntrezGene IDs, the RefSeq DNA IDs, the Panther molecular function, the q-values, the mean of the ratios of the different experiments (M) and the standard error of the mean (SEM) are shown.
Table S3 -
NTG- or PETN-induced changes in the mRNA expression of transcription factors in rat hearts. NTG- vs. EtOH-treated or PETN- vs. DMSO-treated ratio values (mean ± SEM) of transcription factors genes with changes in the expression induced by NTG- or PETN-treatment (only genes with q-values < 5% are shown; ns q-value > 5%). Genes are arranged according the Ensembl gene ID. The Ensembl gene IDs, the gene names, the gene descriptions, the EntrezGene IDs, the RefSeq DNA IDs, the q-values, the mean of the ratios of the different experiments (M) and the standard error of the mean (SEM) are shown.
Table S4 -
Genes whose 5'-flanking sequences were used for the analysis of putative transcription factor binding sites. NTG- vs. EtOH-treated or PETN- vs. DMSO-treated ratio values (mean ± SEM) of genes with changes in the expression induced by NTG- or PETN-treatment (only genes with q-values < 5% are shown; ns q-value > 5%). These genes have been described in the literature to be involved either protective or toxic in the pathogenesis of heart diseases. Genes are arranged according the Ensembl gene ID. The Ensembl gene IDs, the gene names, the gene descriptions, the EntrezGene IDs, the RefSeq DNA IDs, the Panther molecular function, the q-values, the mean of the ratios of the different experiments (M) and the standard error of the mean (SEM) are shown. Also the described cardioprotective (P) or cardiotoxic (T) effects are indicated.