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Invited Review

Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila

Genome Sequence Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 4E6

Programmed cell death (PCD) is an essential and wide-spread physiological process that results in the elimination of cells. Genes required to carry out this process have been identified, and many of these remain the subjects of intense investigation. Here, we describe PCD, its functions, and some of the consequences when it goes awry. We review PCD in the model system, the fruit fly, Drosophila melanogaster, with a particular emphasis on cell death gene discovery resulting from both genetics and genomics-based approaches.

apoptosis; fruit fly; genome project